Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 13354..13939 | Replicon | plasmid unnamed |
| Accession | NZ_CP083182 | ||
| Organism | Acinetobacter baumannii strain AB43 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N8R027 |
| Locus tag | K9O37_RS18835 | Protein ID | WP_004698338.1 |
| Coordinates | 13354..13674 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K9O37_RS18840 | Protein ID | WP_000369781.1 |
| Coordinates | 13667..13939 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9O37_RS18810 (K9O37_18725) | 8501..8761 | - | 261 | WP_005000600.1 | hypothetical protein | - |
| K9O37_RS18815 (K9O37_18730) | 8997..10625 | + | 1629 | WP_163078281.1 | MobQ family relaxase | - |
| K9O37_RS18820 (K9O37_18735) | 11185..12117 | + | 933 | WP_147508592.1 | replication initiation protein RepM | - |
| K9O37_RS18825 (K9O37_18740) | 12196..12717 | + | 522 | WP_004676375.1 | plasmid replication DNA-binding protein | - |
| K9O37_RS18830 (K9O37_18745) | 12927..13187 | - | 261 | WP_004698336.1 | hypothetical protein | - |
| K9O37_RS18835 (K9O37_18750) | 13354..13674 | + | 321 | WP_004698338.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K9O37_RS18840 (K9O37_18755) | 13667..13939 | + | 273 | WP_000369781.1 | NadS family protein | Antitoxin |
| K9O37_RS18845 (K9O37_18760) | 14019..14339 | - | 321 | WP_163078293.1 | DUF6176 family protein | - |
| K9O37_RS18850 (K9O37_18765) | 14947..15303 | + | 357 | WP_000269904.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K9O37_RS18855 (K9O37_18770) | 15296..15598 | + | 303 | WP_024436604.1 | XRE family transcriptional regulator | - |
| K9O37_RS18860 (K9O37_18775) | 15591..15800 | + | 210 | WP_000069475.1 | hypothetical protein | - |
| K9O37_RS18865 (K9O37_18780) | 15975..16493 | + | 519 | WP_000447196.1 | tetratricopeptide repeat protein | - |
| K9O37_RS18870 (K9O37_18785) | 16532..17044 | + | 513 | WP_024436968.1 | SMI1/KNR4 family protein | - |
| K9O37_RS18875 (K9O37_18790) | 17227..17655 | + | 429 | WP_016653412.1 | hypothetical protein | - |
| K9O37_RS18880 (K9O37_18795) | 17880..18107 | - | 228 | Protein_23 | recombinase family protein | - |
| K9O37_RS18885 (K9O37_18800) | 18162..18866 | - | 705 | WP_004741406.1 | IS6-like element IS1006 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..104309 | 104309 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12222.01 Da Isoelectric Point: 6.9800
>T216184 WP_004698338.1 NZ_CP083182:13354-13674 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQEDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLLAY
PKSVKDNLTDKETAILRQLVKEQFHG
MLFIETSIFTKQIKDLVSDEEYRQLQEDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLLAY
PKSVKDNLTDKETAILRQLVKEQFHG
Download Length: 321 bp
>T216184 NZ_CP112996:c756665-756357 [Mycobacterium tuberculosis variant bovis]
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA
ATGCGGCGCGGTGAATTGTGGTTTGCCGCCACACCTGGTGGTGACAGACCAGTACTTGTCCTTACCAGAGATCCGGTGGC
AGACCGCATCGGCGCGGTCGTTGTGGTGGCCCTAACCCGCACCCGCCGAGGCCTGGTGTCGGAATTGGAGCTCACGGCCG
TCGAAAACCGTGTTCCGAGCGACTGCGTCGTCAACTTCGACAACATTCATACGTTGCCACGCACCGCATTCCGACGCCGC
ATCACCCGGCTGTCCCCGGCCCGCCTGCACGAAGCCTGTCAAACACTCCGGGCGAGCACGGGGTGTTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10149.61 Da Isoelectric Point: 8.6582
>AT216184 WP_000369781.1 NZ_CP083182:13667-13939 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
Download Length: 273 bp
>AT216184 NZ_CP112996:c756897-756652 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|