Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 360307..360953 Replicon chromosome
Accession NZ_CP083075
Organism Klebsiella pneumoniae strain 0113481141

Toxin (Protein)


Gene name higB Uniprot ID A0A4S7KZ03
Locus tag K9F42_RS01665 Protein ID WP_032433636.1
Coordinates 360307..360654 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A4S7L580
Locus tag K9F42_RS01670 Protein ID WP_019725405.1
Coordinates 360654..360953 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F42_RS01655 (356233) 356233..357666 + 1434 WP_032433640.1 glycogen synthase GlgA -
K9F42_RS01660 (357684) 357684..360131 + 2448 WP_032433638.1 glycogen phosphorylase -
K9F42_RS01665 (360307) 360307..360654 + 348 WP_032433636.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F42_RS01670 (360654) 360654..360953 + 300 WP_019725405.1 XRE family transcriptional regulator Antitoxin
K9F42_RS01675 (361016) 361016..362524 - 1509 WP_029602548.1 glycerol-3-phosphate dehydrogenase -
K9F42_RS01680 (362729) 362729..363058 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K9F42_RS01685 (363109) 363109..363939 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
K9F42_RS01690 (363989) 363989..364747 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13500.51 Da        Isoelectric Point: 6.2327

>T216127 WP_032433636.1 NZ_CP083075:360307-360654 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGINEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T216127 NZ_CP112887:676568-676882 [Raoultella electrica]
ATGCAATTCACCGTATATGCGAATACTGGTAAAAGCACCGTTTACCCTCTGCTGCTCGATGTCACCAGCGATATTATTGG
ACAACTGAACCGCCGGATAGTGATCCCGCTGCTGCCGGTTGACAGGTATCCGGCAGGCCACCGCCCGGATCGCCTTGTTC
CCTTCGTCAGTCTGACAGACGGCAGAGAATACGCGGTAATGACCCACGAGCTGGCAAGTATCCCGGTTCAGGCGCTGGGG
GCGGTGTTTTGCGATGCTGCGCAGTACCGTTCGCAGGTAAAGGCTGCAATTGATTTTCTCATTGACGGCATTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10775.53 Da        Isoelectric Point: 9.7681

>AT216127 WP_019725405.1 NZ_CP083075:360654-360953 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKSYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT216127 NZ_CP112887:676329-676565 [Raoultella electrica]
ATGGCAGCGAAACAGCGCAGCACACAGAGCGTGACCATGACGGTGGAACGCGCCTTACTGGCCCGGGCGCGTGAGGCAGG
CATTAACCTGAGTGCGACCCTGACAGCCGCGTTAGATGCCGAGCTTCGGCACCATGAAGCGAAAAAATGGCAGGAAGAGA
ACAGGGAAGCCATTGAAGCACTAAATCGTTTCCATGATGAGCATGGCTGTTTCAGCGATGAGTACAGGACATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S7KZ03

Antitoxin

Source ID Structure
AlphaFold DB A0A4S7L580

References