Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 334120..334706 Replicon chromosome
Accession NZ_CP083075
Organism Klebsiella pneumoniae strain 0113481141

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag K9F42_RS01555 Protein ID WP_002920800.1
Coordinates 334338..334706 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K9F42_RS01550 Protein ID WP_004174006.1
Coordinates 334120..334341 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F42_RS01530 (330277) 330277..331203 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K9F42_RS01535 (331200) 331200..332477 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
K9F42_RS01540 (332474) 332474..333241 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K9F42_RS01545 (333243) 333243..333956 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K9F42_RS01550 (334120) 334120..334341 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K9F42_RS01555 (334338) 334338..334706 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K9F42_RS01560 (334979) 334979..336295 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K9F42_RS01565 (336402) 336402..337289 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K9F42_RS01570 (337286) 337286..338131 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K9F42_RS01575 (338133) 338133..339203 + 1071 WP_032433652.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 332474..339940 7466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T216126 WP_002920800.1 NZ_CP083075:334338-334706 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T216126 NZ_CP112881:313160-314026 [Sneathiella aquimaris]
ATGGCTAAGCAACCGAAAGATATAGCCGCATCCGTTCGGCAGCGCTTGCTGAACCTAGCGCGTGAAGAGCAGCGTGTTTT
TGAAGTCGTTCTTGTTGCTTTCGGTTTGGAAAGATTGATCTATCGCCTTTCCGTTTCTGACTACCGGGAGCGGTTTGTTC
TAAAAGGAGGAATGCTCGTTACGCTTTGGACCACAGATCCAGGACGATTTACACGTGACGTAGATTTTCTCGGTTTTGGT
GACGATGATGAGGGGCAATTAAAAGCAGTGTTCGCGGAAATCCTTGCTATGGACGTCAATGATGGCCTCACGTTTGATAG
TGCTGATATCTCGGCATCTGATATTAGAGAAGATCAAGTCTATGGCGGCAAGCGTTTGAAGACGACTGCCTATCTGGGGA
AAATACGCATTCCGATCACAATAGATCTCGGTTTCGGTGATACTTTGGGCGATCCAAAATTCGAGATCGAATATACTTCT
CTGCTCGACTTCGAGGCGGCAAAAATCCGAGCATATTCGCCAGCCACAGTGATTGCTGAGAAATTTCAAGCTGTAGTCGA
TCTTGGTGTGGTGAACGGACGAATGAAAGATTTTTACGACCTCTGGGCCGTGCCAAAAGCCAAAGAAATACCGGATAATG
ATCTCGCGCGTGCACTCAAATCTACATTTGATAGAAGGCATACAGAAATTCCAACCGACAGACCACCTGGTTTATCGGAG
GAGTTTGCTACCGAACCTGCGAAGGTTACACAATGGACTGCCTATGCTGAATCCACCGAACTTGAGGACGTATCACTAGA
AGCTGTGGTTGACGAAATTTGGGAACGGCTCGCTCCTATTTGCCTAGCTGCTTCCAAACTCTCATGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT216126 WP_004174006.1 NZ_CP083075:334120-334341 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT216126 NZ_CP112881:312592-313167 [Sneathiella aquimaris]
ATGGCCCGCCACCCGCTCGCGCGACCCCGTGACCTCCGCGAGGTCGGAGTCACTGGAACCGTGATAAAACGCGCTATGGA
CGACGGCGATATTATTCGGATCGGTCGAGGACTTTACCAGCTCACAGGGACCGATATCGAGCTTAACGCCAGTCTCGCGG
AAGTCAGCAAGCAAGCACCCAAGGCCATTATCTGCCTCATGTCGGCGCTCTCATTTCACGGGCTCACGGATCAACTGCCG
CGTAAAGTATGGATCGCCATTGGCGCCAAAGATTGGAAGCCAAAAATTTCCTATCCGAGAACGCGAACGGTACGATTTCG
AGAGCCTTACCTTTCGAAAGGTGTAGAGAGTTTCAAAATCGGTAGTGTCGATGTAAAAATATACTCCGCCGCCAAATCGA
TTGCGGACGCTTTTAGAAACCCAAAACTGGTCGACCGCTCCGTAGCGATTGAGTGTCTTAAAACCGCTCTAGAAACGCGC
AAAGCATCGCCAGCTAGTCTAGCGAATGCCGCAGAAAATTATGGGGTCGGTAAACTGATGCGCCCCTATCTGGAGGCGCT
GACATCAAATGGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References