Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 452430..453124 | Replicon | chromosome |
| Accession | NC_008150 | ||
| Organism | Yersinia pestis Antiqua | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | A0A0E1NW62 |
| Locus tag | YPA_RS02105 | Protein ID | WP_002214787.1 |
| Coordinates | 452430..452726 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | Q666X1 |
| Locus tag | YPA_RS02110 | Protein ID | WP_002209924.1 |
| Coordinates | 452726..453124 (+) | Length | 133 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| YPA_RS02065 | 447541..447732 | + | 192 | Protein_374 | DUF4102 domain-containing protein | - |
| YPA_RS02070 | 447798..448580 | - | 783 | WP_001317493.1 | IS21-like element IS100kyp family helper ATPase IstB | - |
| YPA_RS02075 | 448577..449601 | - | 1025 | Protein_376 | IS21 family transposase | - |
| YPA_RS02080 | 449658..450716 | + | 1059 | WP_002220106.1 | tyrosine-type recombinase/integrase | - |
| YPA_RS02085 | 450798..450983 | - | 186 | WP_002209928.1 | hypothetical protein | - |
| YPA_RS02095 | 451581..451841 | + | 261 | WP_002214785.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YPA_RS02100 | 451904..452266 | + | 363 | WP_002209925.1 | helix-turn-helix domain-containing protein | - |
| YPA_RS02105 | 452430..452726 | + | 297 | WP_002214787.1 | type II toxin-antitoxin system MqsR family toxin | Toxin |
| YPA_RS02110 | 452726..453124 | + | 399 | WP_002209924.1 | type II toxin-antitoxin system MqsA family antitoxin | Antitoxin |
| YPA_RS02115 | 453524..455815 | - | 2292 | WP_002209923.1 | toprim domain-containing protein | - |
| YPA_RS02120 | 456115..456441 | + | 327 | WP_002209922.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| YPA_RS25470 | 456434..456586 | + | 153 | WP_002209921.1 | hypothetical protein | - |
| YPA_RS02130 | 456600..456800 | - | 201 | WP_002209920.1 | AlpA family transcriptional regulator | - |
| YPA_RS02135 | 456982..457314 | - | 333 | WP_002214791.1 | hypothetical protein | - |
| YPA_RS02140 | 457320..457556 | - | 237 | WP_002214792.1 | hypothetical protein | - |
| YPA_RS02145 | 457569..457934 | - | 366 | WP_002209919.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11319.12 Da Isoelectric Point: 7.8810
>T21600 WP_002214787.1 NC_008150:452430-452726 [Yersinia pestis Antiqua]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI
Download Length: 297 bp
>T21600 NC_008150:452430-452726 [Yersinia pestis Antiqua]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA
Antitoxin
Download Length: 133 a.a. Molecular weight: 14657.17 Da Isoelectric Point: 8.4923
>AT21600 WP_002209924.1 NC_008150:452726-453124 [Yersinia pestis Antiqua]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR
Download Length: 399 bp
>AT21600 NC_008150:452726-453124 [Yersinia pestis Antiqua]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1NW62 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q666X1 |