Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3465544..3466238 Replicon chromosome
Accession NC_008149
Organism Yersinia pestis Nepal516

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag YPN_RS16250 Protein ID WP_002214787.1
Coordinates 3465942..3466238 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag YPN_RS16245 Protein ID WP_002209924.1
Coordinates 3465544..3465942 (-) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPN_RS16210 3460734..3461099 + 366 WP_002209919.1 hypothetical protein -
YPN_RS16215 3461112..3461348 + 237 WP_002214792.1 hypothetical protein -
YPN_RS16220 3461354..3461686 + 333 WP_002214791.1 hypothetical protein -
YPN_RS16225 3461868..3462068 + 201 WP_002209920.1 AlpA family transcriptional regulator -
YPN_RS24010 3462082..3462234 - 153 WP_002209921.1 hypothetical protein -
YPN_RS16235 3462227..3462553 - 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPN_RS16240 3462853..3465144 + 2292 WP_002209923.1 toprim domain-containing protein -
YPN_RS16245 3465544..3465942 - 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
YPN_RS16250 3465942..3466238 - 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
YPN_RS16255 3466402..3466764 - 363 WP_002209925.1 helix-turn-helix domain-containing protein -
YPN_RS16260 3466827..3467087 - 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
YPN_RS16270 3467685..3467870 + 186 WP_002209928.1 hypothetical protein -
YPN_RS16275 3467952..3469166 - 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
YPN_RS16285 3469599..3471116 - 1518 WP_002209930.1 lysine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T21597 WP_002214787.1 NC_008149:c3466238-3465942 [Yersinia pestis Nepal516]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T21597 NC_008149:c3466238-3465942 [Yersinia pestis Nepal516]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGAATGTCTCGTTTAAGGAGATTTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT21597 WP_002209924.1 NC_008149:c3465942-3465544 [Yersinia pestis Nepal516]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT21597 NC_008149:c3465942-3465544 [Yersinia pestis Nepal516]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References