Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 13609..14266 | Replicon | plasmid p1-7008.20 |
| Accession | NZ_CP082989 | ||
| Organism | Klebsiella pneumoniae strain 7008.20 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | K9F32_RS26240 | Protein ID | WP_000270043.1 |
| Coordinates | 13916..14266 (-) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K9F32_RS26235 | Protein ID | WP_000124640.1 |
| Coordinates | 13609..13911 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9F32_RS26190 (K9F32_26120) | 9234..9662 | + | 429 | WP_000591074.1 | hypothetical protein | - |
| K9F32_RS26195 (K9F32_26125) | 9719..10078 | + | 360 | WP_000422768.1 | hypothetical protein | - |
| K9F32_RS26200 (K9F32_26130) | 10078..10524 | + | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| K9F32_RS26205 (K9F32_26135) | 10521..11039 | + | 519 | WP_000210756.1 | nitrite reductase | - |
| K9F32_RS26210 (K9F32_26140) | 11039..11269 | + | 231 | WP_000972663.1 | hypothetical protein | - |
| K9F32_RS26215 (K9F32_26145) | 11256..12113 | + | 858 | WP_001167032.1 | hypothetical protein | - |
| K9F32_RS26220 (K9F32_26150) | 12344..12871 | + | 528 | WP_001236377.1 | thermonuclease family protein | - |
| K9F32_RS26225 (K9F32_26155) | 12929..13201 | + | 273 | WP_001043047.1 | HU family DNA-binding protein | - |
| K9F32_RS26230 (K9F32_26160) | 13289..13582 | + | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| K9F32_RS26235 (K9F32_26165) | 13609..13911 | - | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| K9F32_RS26240 (K9F32_26170) | 13916..14266 | - | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K9F32_RS26245 (K9F32_26175) | 14429..14977 | + | 549 | WP_001061574.1 | transcriptional regulator | - |
| K9F32_RS26250 (K9F32_26180) | 15318..15512 | + | 195 | WP_000343597.1 | hypothetical protein | - |
| K9F32_RS26255 (K9F32_26185) | 15523..15894 | + | 372 | WP_000516916.1 | hypothetical protein | - |
| K9F32_RS26260 (K9F32_26190) | 15887..16357 | + | 471 | WP_001281821.1 | hypothetical protein | - |
| K9F32_RS26265 (K9F32_26195) | 16372..16707 | - | 336 | WP_000683476.1 | hypothetical protein | - |
| K9F32_RS26270 (K9F32_26200) | 16804..17292 | + | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| K9F32_RS26275 (K9F32_26205) | 17295..17792 | + | 498 | WP_000062185.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aph(3')-Ia / qnrS1 / floR / sul2 / sul1 / qacE / ant(3'')-Ia / blaOXA-10 / cmlA1 / ARR-3 / dfrA14 / blaCTX-M-15 / blaTEM-1C / mph(A) | - | 1..174853 | 174853 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T215813 WP_000270043.1 NZ_CP082989:c14266-13916 [Klebsiella pneumoniae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T215813 NZ_CP110962:1996280-1996382 [Klebsiella pneumoniae subsp. pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT215813 WP_000124640.1 NZ_CP082989:c13911-13609 [Klebsiella pneumoniae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT215813 NZ_CP110962:c1996389-1996244 [Klebsiella pneumoniae subsp. pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|