Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
| Location | 1920161..1920683 | Replicon | chromosome |
| Accession | NZ_CP082961 | ||
| Organism | Lacticaseibacillus rhamnosus strain CAU 1365 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | C2JUK2 |
| Locus tag | K6087_RS08775 | Protein ID | WP_005687756.1 |
| Coordinates | 1920423..1920683 (+) | Length | 87 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | C2JUK3 |
| Locus tag | K6087_RS08770 | Protein ID | WP_005687754.1 |
| Coordinates | 1920161..1920430 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6087_RS08755 (K6087_08750) | 1915648..1917516 | - | 1869 | WP_014571687.1 | HTH domain-containing protein | - |
| K6087_RS08760 (K6087_08755) | 1917543..1918343 | - | 801 | WP_005690776.1 | SDR family oxidoreductase | - |
| K6087_RS08765 (K6087_08760) | 1918949..1919965 | - | 1017 | WP_019728331.1 | IS30 family transposase | - |
| K6087_RS08770 (K6087_08765) | 1920161..1920430 | + | 270 | WP_005687754.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| K6087_RS08775 (K6087_08770) | 1920423..1920683 | + | 261 | WP_005687756.1 | Txe/YoeB family addiction module toxin | Toxin |
| K6087_RS08780 (K6087_08775) | 1920894..1921622 | - | 729 | WP_014571689.1 | L-ribulose-5-phosphate 4-epimerase | - |
| K6087_RS08785 (K6087_08780) | 1921819..1922640 | + | 822 | WP_005690770.1 | Cof-type HAD-IIB family hydrolase | - |
| K6087_RS08790 (K6087_08785) | 1922707..1923594 | - | 888 | WP_014571690.1 | L-ribulose-5-phosphate 3-epimerase | - |
| K6087_RS08795 (K6087_08790) | 1923779..1924558 | - | 780 | WP_005690765.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| K6087_RS08800 (K6087_08795) | 1924626..1925267 | - | 642 | WP_005690763.1 | 3-keto-L-gulonate-6-phosphate decarboxylase UlaD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 87 a.a. Molecular weight: 10485.91 Da Isoelectric Point: 9.6577
>T215713 WP_005687756.1 NZ_CP082961:1920423-1920683 [Lacticaseibacillus rhamnosus]
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS
MIKTWTDDAWADYMYWHDQNDKRTIKRINQLIQAIDRDPYKGIGKPEPLRYALTGKWSRRIDQENRIIYSIEKNHINIFA
CRTHYS
Download Length: 261 bp
>T215713 NZ_CP110921:2254287-2254970 [Methylococcus sp. 16-5]
ATGGTCGAAAGCCAGGAACAGGTGGCGACCTATCGGATCGTGTCTTCCCTGGAAGAACAGGCCCTACTGGAAGAACTTCT
GGAAACGTCCAAACCCTCGCCGCCGGAAACCGCCGGGGATTTCCATTACCTGCTCACAACCCCTTTCCGCTACCCGCCCC
TGCGCCATGGCTCTCGCTTTGGCCGGCGGCACGAACCCAGCCTGTTCTATGGTTCGGCCACTGTCGACACGATGCTGGCC
GAAGTTGCCTACTACCGCTTCGTGTTCTGGCAAGGCATGGAAACGCCGCCTCAAGCACCCATCGTCACCCAGCACACCGT
GTTCAGCGCACGCTATGCCTGCGACAGGAGTTTGAAACTGCAAGATCCGCCCTTCGACGCTTGGCGTGCGGCGCTGACCG
ACCCCGGGCACTATGCGGCCACCCAGGACCTGGGAAGCGCGATGAGAGAAGCCGGTGTTCAAGCGTTCGAGTACGTGTCG
GCACGGGATCCGGCAGGGGGAATCAACGTCGCCTTGTTCGAGCCCGCTGCGCTGGCCGACAAACGGCCGGTCGAATGCCA
GAACTGGCTCGCGGAAACCTCGGGAGAACGCGTGGCGTTCTTGGGCGAGGCGAGGCAGATTCGAGGTTTCGAGCTTGAAA
CCCTCCTGGTCGAGGGTATGTTGCCTGCGCCAGCCGTTTGCTGA
ATGGTCGAAAGCCAGGAACAGGTGGCGACCTATCGGATCGTGTCTTCCCTGGAAGAACAGGCCCTACTGGAAGAACTTCT
GGAAACGTCCAAACCCTCGCCGCCGGAAACCGCCGGGGATTTCCATTACCTGCTCACAACCCCTTTCCGCTACCCGCCCC
TGCGCCATGGCTCTCGCTTTGGCCGGCGGCACGAACCCAGCCTGTTCTATGGTTCGGCCACTGTCGACACGATGCTGGCC
GAAGTTGCCTACTACCGCTTCGTGTTCTGGCAAGGCATGGAAACGCCGCCTCAAGCACCCATCGTCACCCAGCACACCGT
GTTCAGCGCACGCTATGCCTGCGACAGGAGTTTGAAACTGCAAGATCCGCCCTTCGACGCTTGGCGTGCGGCGCTGACCG
ACCCCGGGCACTATGCGGCCACCCAGGACCTGGGAAGCGCGATGAGAGAAGCCGGTGTTCAAGCGTTCGAGTACGTGTCG
GCACGGGATCCGGCAGGGGGAATCAACGTCGCCTTGTTCGAGCCCGCTGCGCTGGCCGACAAACGGCCGGTCGAATGCCA
GAACTGGCTCGCGGAAACCTCGGGAGAACGCGTGGCGTTCTTGGGCGAGGCGAGGCAGATTCGAGGTTTCGAGCTTGAAA
CCCTCCTGGTCGAGGGTATGTTGCCTGCGCCAGCCGTTTGCTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10181.39 Da Isoelectric Point: 4.6755
>AT215713 WP_005687754.1 NZ_CP082961:1920161-1920430 [Lacticaseibacillus rhamnosus]
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD
MEATNYSDFRRNLKHYMSQVNEDAEPLLVTAKDDDDNVVVMSKHDFDAIEETLYLLSNPKLMAKIKRGDAQIAAGKAKQH
ELLTDFDHD
Download Length: 270 bp
>AT215713 NZ_CP110921:2253862-2254221 [Methylococcus sp. 16-5]
ATGAATACCGTAGCCAAGGCCAAGCCGGAGCCCTCGTCCGTTTTGGGACGCGCCTTTCTGGAGGCGGGCAGGAAACTTGG
ACTGAGCCAGTCGGTACTGGAGGTCACGATCGCTCGCAACCGGAGCTCGATCAGCCGCAATGGCATCGACCCGGCCAGCA
AGTCCGGGGAATTGGCGCTGCTGCTGATCCGGATTTACCGGTCCCTGTTTGCGCTGATGGGGGGCGATGAAGCGCAGATG
GCGCACTGGATGAAGACCCGCAATCGGCACACCGGCGGTATTCCGGCGGAACAGATCCGCAGCGTTCAAGGCCTGGTGGG
CGTTGTGGAATACCTCGATGCCATGCGAGGGAAAATTTGA
ATGAATACCGTAGCCAAGGCCAAGCCGGAGCCCTCGTCCGTTTTGGGACGCGCCTTTCTGGAGGCGGGCAGGAAACTTGG
ACTGAGCCAGTCGGTACTGGAGGTCACGATCGCTCGCAACCGGAGCTCGATCAGCCGCAATGGCATCGACCCGGCCAGCA
AGTCCGGGGAATTGGCGCTGCTGCTGATCCGGATTTACCGGTCCCTGTTTGCGCTGATGGGGGGCGATGAAGCGCAGATG
GCGCACTGGATGAAGACCCGCAATCGGCACACCGGCGGTATTCCGGCGGAACAGATCCGCAGCGTTCAAGGCCTGGTGGG
CGTTGTGGAATACCTCGATGCCATGCGAGGGAAAATTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249N526 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249N594 |