Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4045634..4046221 Replicon chromosome
Accession NC_008009
Organism Candidatus Koribacter versatilis Ellin345

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ACID345_RS17705 Protein ID WP_041855842.1
Coordinates 4045940..4046221 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ACID345_RS17700 Protein ID WP_011524224.1
Coordinates 4045634..4045930 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ACID345_RS17685 4041527..4042360 + 834 WP_011524221.1 hypothetical protein -
ACID345_RS17690 4042360..4043037 + 678 WP_011524222.1 hypothetical protein -
ACID345_RS17695 4043037..4045502 + 2466 WP_011524223.1 hypothetical protein -
ACID345_RS17700 4045634..4045930 - 297 WP_011524224.1 HigA family addiction module antidote protein Antitoxin
ACID345_RS17705 4045940..4046221 - 282 WP_041855842.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ACID345_RS17710 4046294..4048147 + 1854 WP_011524226.1 bifunctional homocysteine S-methyltransferase/methylenetetrahydrofolate reductase -
ACID345_RS17715 4048239..4048469 + 231 WP_011524227.1 exodeoxyribonuclease VII small subunit -
ACID345_RS17720 4048544..4048918 + 375 WP_041855843.1 hypothetical protein -
ACID345_RS17725 4049070..4049471 + 402 WP_041856877.1 dehydrogenase -
ACID345_RS17730 4049479..4050603 - 1125 WP_011524229.1 ATP-dependent DNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10820.37 Da        Isoelectric Point: 8.0551

>T21571 WP_041855842.1 NC_008009:c4046221-4045940 [Candidatus Koribacter versatilis Ellin345]
VIVSFKDPDARLLYETGKSRRIPATLRKAAMRKLVTLNNVDELDHLEIPPGNRLEPMKGDRTGQHSIRINDQFRVCFIWR
DGNAYEVEIVDYH

Download         Length: 282 bp

>T21571 NC_008009:c4046221-4045940 [Candidatus Koribacter versatilis Ellin345]
GTGATCGTCAGCTTCAAGGACCCCGATGCAAGACTCCTCTACGAAACGGGGAAAAGCAGACGTATTCCAGCAACGCTTCG
GAAAGCCGCGATGCGTAAGTTGGTCACACTGAATAACGTTGACGAGTTGGATCATCTCGAGATTCCGCCGGGGAATCGTC
TTGAACCAATGAAGGGCGATCGGACCGGGCAACACAGTATTCGGATCAATGATCAATTTCGAGTGTGTTTCATTTGGCGA
GACGGAAACGCTTACGAAGTTGAGATCGTTGACTATCACTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11301.32 Da        Isoelectric Point: 10.7702

>AT21571 WP_011524224.1 NC_008009:c4045930-4045634 [Candidatus Koribacter versatilis Ellin345]
MAGKKPWAIHPGELLREEFMRPLGLTSYRLAKELHVPLPRINDLVREHRAMTADTALRLEKYFGMPARFWMNVQVDYDIR
TAAKKADVSKIKPRKAAA

Download         Length: 297 bp

>AT21571 NC_008009:c4045930-4045634 [Candidatus Koribacter versatilis Ellin345]
ATGGCGGGGAAGAAACCGTGGGCGATTCATCCGGGCGAACTGCTCCGTGAGGAGTTCATGCGACCTCTAGGTCTCACCTC
CTACCGCCTCGCTAAAGAACTGCACGTGCCTCTGCCTCGGATTAACGACCTTGTGCGGGAGCATCGTGCGATGACGGCGG
ATACTGCGCTGCGCCTGGAAAAGTACTTCGGGATGCCGGCGCGGTTCTGGATGAACGTTCAGGTCGACTACGACATCCGA
ACTGCTGCCAAGAAGGCGGACGTATCGAAGATCAAGCCGCGCAAAGCCGCCGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References