Detailed information of TA system TA215705

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2218..2487
• Replicon: plasmid unnamed4
• Accession: NZ_CP082958
• Organism: Salmonella enterica subsp. arizonae strain S499

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: K8I78_RS26475
• Protein ID: WP_241226816.1
• Coordinates: 2371..2487 (+)
• Length: 39 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	2218..2283 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8I78_RS26460	899..1333	+	435	WP_032217500.1	conjugation system SOS inhibitor PsiB	-
K8I78_RS26465	1330..2092	+	763	Protein_2	plasmid SOS inhibition protein A	-
-	2061..2285	+	225	NuclAT_0	-	-
-	2061..2285	+	225	NuclAT_0	-	-
-	2061..2285	+	225	NuclAT_0	-	-
-	2061..2285	+	225	NuclAT_0	-	-
-	2218..2283	-	66	-	-	Antitoxin
K8I78_RS26470	2271..2420	+	150	Protein_3	plasmid maintenance protein Mok	-
K8I78_RS26475	2371..2487	+	117	WP_241226816.1	type I toxin-antitoxin system Hok family toxin	Toxin
K8I78_RS26480	2707..2937	+	231	WP_001426396.1	hypothetical protein	-
K8I78_RS26485	2935..3108	-	174	Protein_6	hypothetical protein	-
K8I78_RS26490	3178..3384	+	207	WP_000547971.1	hypothetical protein	-
K8I78_RS26495	3409..3696	+	288	WP_000107535.1	hypothetical protein	-
K8I78_RS26500	3814..4635	+	822	WP_001234469.1	DUF932 domain-containing protein	-
K8I78_RS26505	4932..5579	-	648	WP_000614935.1	transglycosylase SLT domain-containing protein	-
K8I78_RS26510	5856..6239	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
K8I78_RS26515	6430..7116	+	687	WP_015059009.1	PAS domain-containing protein	-
K8I78_RS26520	7210..7437	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaTEM-1B / blaCTX-M-55	-	1..67319	67319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (1-34)

Sequences

Toxin

Protein

• Length: 39 a.a.
• Molecular weight: 4455.23 Da
• Isoelectric Point: 8.5110

>T215705 WP_241226816.1 NZ_CP082958:2371-2487 [Salmonella enterica subsp. arizonae]
VCLTLLIFTYLTRKSLCELRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 117 bp

>T215705 NZ_CP110896:82722-82997 [Citrobacter freundii]
ATGACACGCTACCGGACAGAATACACAAAACGGTTCGTCAAAGAGTTTAAGAAAATTGACACGGTACACCAGAGGGTAAT
TCAGAAGTACATTGAGGCGCACATCAACAACGCACTCAATCCGCGCTTGACGGGTAAAATCCTGAAAGGAGATAAAGCCG
AATTTATCCGCTGGCGTATCGGTGATTACCGTCTGATTGCCACTATTGAAGACGATAAATTGCTGGTCATTGCGTTAAGC
GTGGGACACCGCAAAGACGTGTACAAAAAGTTTTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT215705 NZ_CP082958:c2283-2218 [Salmonella enterica subsp. arizonae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin