Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 114105..114762 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP082956 | ||
| Organism | Salmonella enterica subsp. arizonae strain S499 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U3PDC3 |
| Locus tag | K8I78_RS25565 | Protein ID | WP_000270043.1 |
| Coordinates | 114105..114455 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K8I78_RS25570 | Protein ID | WP_000124640.1 |
| Coordinates | 114460..114762 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8I78_RS25520 (K8I78_25360) | 109416..109595 | + | 180 | Protein_127 | helix-turn-helix domain-containing protein | - |
| K8I78_RS25525 (K8I78_25365) | 109660..110364 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| K8I78_RS25530 (K8I78_25370) | 110579..111076 | - | 498 | WP_000062185.1 | hypothetical protein | - |
| K8I78_RS25535 (K8I78_25375) | 111079..111567 | - | 489 | WP_001273096.1 | DUF1643 domain-containing protein | - |
| K8I78_RS25540 (K8I78_25380) | 111664..111999 | + | 336 | WP_000683476.1 | hypothetical protein | - |
| K8I78_RS25545 (K8I78_25385) | 112014..112484 | - | 471 | WP_001281821.1 | hypothetical protein | - |
| K8I78_RS25550 (K8I78_25390) | 112477..112848 | - | 372 | WP_000516916.1 | hypothetical protein | - |
| K8I78_RS25555 (K8I78_25395) | 112859..113053 | - | 195 | WP_000343597.1 | hypothetical protein | - |
| K8I78_RS25560 (K8I78_25400) | 113394..113942 | - | 549 | WP_001061574.1 | transcriptional regulator | - |
| K8I78_RS25565 (K8I78_25405) | 114105..114455 | + | 351 | WP_000270043.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K8I78_RS25570 (K8I78_25410) | 114460..114762 | + | 303 | WP_000124640.1 | XRE family transcriptional regulator | Antitoxin |
| K8I78_RS25575 (K8I78_25415) | 114789..115082 | - | 294 | WP_001239997.1 | chromosome segregation protein ParM | - |
| K8I78_RS25580 (K8I78_25420) | 115170..115442 | - | 273 | WP_223556225.1 | HU family DNA-binding protein | - |
| K8I78_RS25585 (K8I78_25425) | 115500..116027 | - | 528 | WP_001236377.1 | thermonuclease family protein | - |
| K8I78_RS25590 (K8I78_25430) | 116258..117115 | - | 858 | WP_001167032.1 | hypothetical protein | - |
| K8I78_RS25595 (K8I78_25435) | 117102..117332 | - | 231 | WP_000972663.1 | hypothetical protein | - |
| K8I78_RS25600 (K8I78_25440) | 117332..117850 | - | 519 | WP_000210756.1 | nitrite reductase | - |
| K8I78_RS25605 (K8I78_25445) | 117847..118293 | - | 447 | WP_000919345.1 | Fe3+-siderophore ABC transporter permease | - |
| K8I78_RS25610 (K8I78_25450) | 118293..118652 | - | 360 | WP_000422768.1 | hypothetical protein | - |
| K8I78_RS25615 (K8I78_25455) | 118709..119137 | - | 429 | WP_000591074.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / mph(E) / msr(E) / mph(A) / sul1 / qacE / aadA3 / ARR-3 / dfrA14 | - | 1..152282 | 152282 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 13328.21 Da Isoelectric Point: 5.2421
>T215704 WP_000270043.1 NZ_CP082956:114105-114455 [Salmonella enterica subsp. arizonae]
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
MWVIETTDTFDEWFDALDDTDRANVLASMMVLRDRGPMLSRPYADTVNGSSYSNMKELRVQSKGDPIRAFFAFDPKRKGI
LLCAGNKTGDEKRFYEVMIPIADREFAAHLDKLKKE
Download Length: 351 bp
>T215704 NZ_CP110895:c7703-7437 [Citrobacter freundii]
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGGATTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCATTCTGTGTGAGATCCGGGATGACGAGCTGGTTATCCTTGCCGCCACCATT
GGCCATCGCCGCGAAGTTTACGACTGA
TTGGTCTGGACGATTAACTATTCCGACCGGGCGCTCAAATCGTTACGCAAGATGGACAAACAGAACGCACGACGGATTGT
GGATTTTATGGATTTACGCATTGCAGTTGCTGCCGATCCTCGCCAGTCAGGGAAGCCGCTCAAAGGTGAGCTGGGCGAGT
TCTGGCGCTATCGGGTGGGAGATTATCGCATTCTGTGTGAGATCCGGGATGACGAGCTGGTTATCCTTGCCGCCACCATT
GGCCATCGCCGCGAAGTTTACGACTGA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11006.73 Da Isoelectric Point: 7.2036
>AT215704 WP_000124640.1 NZ_CP082956:114460-114762 [Salmonella enterica subsp. arizonae]
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
MARTLDQMLATEKPEVVAKAQKAATEMLLNIHLAELRDRMNLTQGEIAASLGVRQPTVSEMEKPGRDLKLSSIKRYVEAS
GGKLRLDVELPDGTHYGFAV
Download Length: 303 bp
>AT215704 NZ_CP110895:c7911-7687 [Citrobacter freundii]
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAAGATTATTATCTTTCAGCAGAAACTGCCGCACGCGTTC
GCCGTGGTGATGAAGCCGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
ATGCTTGCTATCCGGTTATCTGATGAGATTGAGTCCCGTCTGGACTCGCTGGCGAAGCAAACCGGCAGAACAAAGACGTT
CTATGCGCGGGAAGCAATACTGGCGCATCTGGAAGACCTGGAAGATTATTATCTTTCAGCAGAAACTGCCGCACGCGTTC
GCCGTGGTGATGAAGCCGTGCATTCGTCTGAAGACGTGAGGAAGTCACTTGGTCTGGACGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|