Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4737326..4738080 | Replicon | chromosome |
| Accession | NZ_CP082954 | ||
| Organism | Salmonella enterica subsp. arizonae strain S499 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | K8I78_RS22670 | Protein ID | WP_000558166.1 |
| Coordinates | 4737326..4737637 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K8I78_RS22675 | Protein ID | WP_001259011.1 |
| Coordinates | 4737634..4738080 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8I78_RS22640 (4732995) | 4732995..4733897 | + | 903 | WP_000331364.1 | formate dehydrogenase subunit beta | - |
| K8I78_RS22645 (4733894) | 4733894..4734529 | + | 636 | WP_000829028.1 | formate dehydrogenase cytochrome b556 subunit | - |
| K8I78_RS22650 (4734526) | 4734526..4735455 | + | 930 | WP_053509958.1 | formate dehydrogenase accessory protein FdhE | - |
| K8I78_RS22655 (4735493) | 4735493..4735867 | - | 375 | WP_023249114.1 | type II toxin-antitoxin system VapC family toxin | - |
| K8I78_RS22660 (4735867) | 4735867..4736109 | - | 243 | WP_001523745.1 | CopG family transcriptional regulator | - |
| K8I78_RS22665 (4736314) | 4736314..4737240 | + | 927 | Protein_4427 | alpha/beta hydrolase | - |
| K8I78_RS22670 (4737326) | 4737326..4737637 | + | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| K8I78_RS22675 (4737634) | 4737634..4738080 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| K8I78_RS22680 (4738095) | 4738095..4739036 | - | 942 | WP_024134888.1 | fatty acid biosynthesis protein FabY | - |
| K8I78_RS22685 (4739081) | 4739081..4739518 | - | 438 | WP_023249111.1 | D-aminoacyl-tRNA deacylase | - |
| K8I78_RS22690 (4739515) | 4739515..4740387 | - | 873 | WP_088760336.1 | virulence factor BrkB family protein | - |
| K8I78_RS22695 (4740381) | 4740381..4740980 | - | 600 | WP_000965699.1 | glucose-1-phosphatase | - |
| K8I78_RS22700 (4741171) | 4741171..4741974 | - | 804 | WP_023249108.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| K8I78_RS22705 (4742008) | 4742008..4742904 | - | 897 | WP_023249107.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T215702 WP_000558166.1 NZ_CP082954:4737326-4737637 [Salmonella enterica subsp. arizonae]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T215702 NZ_CP110894:c4972095-4971721 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT215702 WP_001259011.1 NZ_CP082954:4737634-4738080 [Salmonella enterica subsp. arizonae]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT215702 NZ_CP110894:c4972337-4972095 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGGCAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|