Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 2610067..2610652 | Replicon | chromosome |
| Accession | NZ_CP082952 | ||
| Organism | Acinetobacter baumannii strain Cl300 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N9CJF7 |
| Locus tag | K9C16_RS12535 | Protein ID | WP_000897307.1 |
| Coordinates | 2610067..2610387 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K9C16_RS12540 | Protein ID | WP_000369781.1 |
| Coordinates | 2610380..2610652 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9C16_RS12500 (K9C16_12450) | 2606002..2606289 | + | 288 | WP_000438825.1 | BrnT family toxin | - |
| K9C16_RS12505 (K9C16_12455) | 2606276..2606590 | + | 315 | WP_004728120.1 | BrnA antitoxin family protein | - |
| K9C16_RS12510 (K9C16_12460) | 2606679..2607209 | - | 531 | WP_000172759.1 | hypothetical protein | - |
| K9C16_RS12515 (K9C16_12465) | 2607358..2607660 | + | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K9C16_RS12520 (K9C16_12470) | 2607661..2607942 | + | 282 | WP_000985609.1 | putative addiction module antidote protein | - |
| K9C16_RS12525 (K9C16_12475) | 2608022..2608441 | - | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
| K9C16_RS12530 (K9C16_12480) | 2608604..2609938 | + | 1335 | WP_033917544.1 | ISNCY family transposase | - |
| K9C16_RS12535 (K9C16_12485) | 2610067..2610387 | + | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K9C16_RS12540 (K9C16_12490) | 2610380..2610652 | + | 273 | WP_000369781.1 | NadS family protein | Antitoxin |
| K9C16_RS12545 (K9C16_12495) | 2611145..2612458 | + | 1314 | Protein_2460 | ABC-F type ribosomal protection protein Msr(E) | - |
| K9C16_RS12550 (K9C16_12500) | 2612517..2613221 | + | 705 | WP_001067790.1 | IS6-like element IS1008 family transposase | - |
| K9C16_RS12555 (K9C16_12505) | 2613586..2613903 | - | 318 | WP_029424228.1 | hypothetical protein | - |
| K9C16_RS12560 (K9C16_12510) | 2614277..2614615 | - | 339 | Protein_2463 | hypothetical protein | - |
| K9C16_RS12565 (K9C16_12515) | 2614716..2615174 | - | 459 | WP_029424230.1 | SUKH-3 domain-containing protein | - |
| K9C16_RS12570 (K9C16_12520) | 2615247..2615555 | - | 309 | WP_029424231.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | sul2 | - | 2597129..2610387 | 13258 | |
| - | inside | IScluster/Tn | sul2 / msr(E) | - | 2600268..2613221 | 12953 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12187.95 Da Isoelectric Point: 7.1639
>T215687 WP_000897307.1 NZ_CP082952:2610067-2610387 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG
Download Length: 321 bp
>T215687 NZ_CP110892:c14256-13906 [Citrobacter freundii]
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
ATGTGGGTCATCGAGACAACTGACACCTTTGATGAGTGGTTCGATGCACTGGATGATACCGATAGAGCCAACGTGCTGGC
TTCGATGATGGTGCTGCGAGATAGAGGTCCCATGCTGTCGAGACCATACGCGGATACTGTTAACGGTTCATCCTACAGCA
ACATGAAAGAGCTGCGGGTCCAAAGCAAAGGAGATCCTATCAGGGCATTCTTTGCGTTCGATCCAAAGCGTAAGGGGATT
CTTCTCTGCGCCGGTAACAAGACCGGGGACGAGAAAAGGTTTTATGAAGTAATGATCCCAATTGCAGACCGCGAGTTTGC
GGCGCACTTGGATAAATTGAAGAAGGAGTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10149.61 Da Isoelectric Point: 8.6582
>AT215687 WP_000369781.1 NZ_CP082952:2610380-2610652 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
Download Length: 273 bp
>AT215687 NZ_CP110892:c13901-13599 [Citrobacter freundii]
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
ATGGCAAGAACTCTTGACCAAATGCTGGCAACAGAAAAGCCTGAGGTTGTTGCCAAAGCACAGAAAGCGGCCACTGAGAT
GTTACTGAACATCCACTTGGCAGAGCTTCGTGATCGCATGAACCTTACCCAGGGGGAAATTGCTGCATCTCTGGGTGTGA
GACAGCCGACAGTCTCCGAGATGGAAAAACCTGGACGAGATCTCAAGCTGTCGTCCATTAAGCGGTACGTTGAGGCCTCC
GGTGGCAAGCTACGCCTCGATGTTGAACTTCCGGACGGCACCCACTACGGCTTTGCCGTTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|