Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4476083..4476837 | Replicon | chromosome |
| Accession | NZ_CP082929 | ||
| Organism | Salmonella enterica subsp. enterica serovar London isolate N18-04674 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A3Z1E8E0 |
| Locus tag | K6991_RS21545 | Protein ID | WP_000558163.1 |
| Coordinates | 4476083..4476394 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K6991_RS21550 | Protein ID | WP_001259011.1 |
| Coordinates | 4476391..4476837 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K6991_RS21515 (4471741) | 4471741..4472643 | + | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
| K6991_RS21520 (4472640) | 4472640..4473275 | + | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| K6991_RS21525 (4473272) | 4473272..4474201 | + | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| K6991_RS21530 (4474248) | 4474248..4474538 | - | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| K6991_RS21535 (4474539) | 4474539..4474850 | - | 312 | WP_001159635.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| K6991_RS21540 (4475068) | 4475068..4475997 | + | 930 | WP_023255277.1 | alpha/beta hydrolase | - |
| K6991_RS21545 (4476083) | 4476083..4476394 | + | 312 | WP_000558163.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| K6991_RS21550 (4476391) | 4476391..4476837 | + | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| K6991_RS21555 (4476852) | 4476852..4477793 | - | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| K6991_RS21560 (4477838) | 4477838..4478275 | - | 438 | WP_001621365.1 | D-aminoacyl-tRNA deacylase | - |
| K6991_RS21565 (4478272) | 4478272..4479144 | - | 873 | WP_023255278.1 | virulence factor BrkB family protein | - |
| K6991_RS21570 (4479138) | 4479138..4479737 | - | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| K6991_RS21575 (4479928) | 4479928..4480731 | - | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| K6991_RS21580 (4480765) | 4480765..4481661 | - | 897 | WP_001651900.1 | sugar kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12406.36 Da Isoelectric Point: 9.5921
>T215651 WP_000558163.1 NZ_CP082929:4476083-4476394 [Salmonella enterica subsp. enterica serovar London]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T215651 NZ_CP110873:c981040-980699 [Enterobacter kobei]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGGATCTCGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCGCCTTATCTTCAGGCTGTCGATATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCAGCAAAG
CCGTAGCAACGTAGTACGATGA
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGGATCTCGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCGCCTTATCTTCAGGCTGTCGATATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCAGCAAAG
CCGTAGCAACGTAGTACGATGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT215651 WP_001259011.1 NZ_CP082929:4476391-4476837 [Salmonella enterica subsp. enterica serovar London]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT215651 NZ_CP110873:c981378-981061 [Enterobacter kobei]
ATGACTCACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAAGTCAGCCCCCAACATGCCCACTGCGTCATCATGTACCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGTTACGTGTACATCGCCATTTATCCCACCCAGCGCTAA
ATGACTCACATCACATGGGGCCTGCAGCGGAATATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGGAACCGGCT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAAGTCAGCCCCCAACATGCCCACTGCGTCATCATGTACCAC
AACGGTTTCACCTGTGAAGCCGACACCCTTGGCAGTTGCGGTTACGTGTACATCGCCATTTATCCCACCCAGCGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|