Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2322883..2323405 Replicon chromosome
Accession NZ_CP082929
Organism Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag K6991_RS11210 Protein ID WP_000221343.1
Coordinates 2323121..2323405 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K6991_RS11205 Protein ID WP_000885424.1
Coordinates 2322883..2323131 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6991_RS11180 (2318976) 2318976..2320442 + 1467 WP_077946914.1 hypothetical protein -
K6991_RS11185 (2320744) 2320744..2321034 + 291 WP_000742001.1 hypothetical protein -
K6991_RS11190 (2321387) 2321387..2322113 + 727 Protein_2186 helix-turn-helix domain-containing protein -
K6991_RS11195 (2322194) 2322194..2322526 - 333 WP_000253154.1 DUF1493 family protein -
K6991_RS11200 (2322516) 2322516..2322731 - 216 WP_000206207.1 hypothetical protein -
K6991_RS11205 (2322883) 2322883..2323131 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K6991_RS11210 (2323121) 2323121..2323405 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K6991_RS11215 (2323576) 2323576..2323965 + 390 WP_000194089.1 RidA family protein -
K6991_RS11220 (2324017) 2324017..2325096 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K6991_RS11225 (2325289) 2325289..2325777 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
K6991_RS11230 (2325822) 2325822..2327330 + 1509 WP_058214747.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2318979..2330187 11208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T215642 WP_000221343.1 NZ_CP082929:2323121-2323405 [Salmonella enterica subsp. enterica serovar London]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T215642 NZ_CP110859:3532254-3532532 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT215642 WP_000885424.1 NZ_CP082929:2322883-2323131 [Salmonella enterica subsp. enterica serovar London]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT215642 NZ_CP110859:3531991-3532251 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References