Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 9149..9800 Replicon plasmid 1
Accession NC_007968
Organism Psychrobacter cryohalolentis K5

Toxin (Protein)


Gene name higB Uniprot ID Q1Q7U1
Locus tag PCRYO_RS12795 Protein ID WP_011512335.1
Coordinates 9453..9800 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q1Q7U2
Locus tag PCRYO_RS12790 Protein ID WP_011512377.1
Coordinates 9149..9451 (-) Length 101 a.a.

Genomic Context

PCRYO_RS12785PCRYO_RS12800PCRYO_RS12805PCRYO_RS12770PCRYO_RS12775PCRYO_RS12780PCRYO_RS12790PCRYO_RS12795PCRYO_RS12810PCRYO_RS12815PCRYO_RS12820
Location: 8397..8756 (360 bp)
Type: Others
Protein ID: WP_041753786.1
Location: 10053..10649 (597 bp)
Type: Others
Protein ID: WP_011512336.1
Location: 10814..12397 (1584 bp)
Type: Others
Protein ID: WP_105575658.1
Location: 4248..4772 (525 bp)
Type: Others
Protein ID: WP_011512374.1
Location: 4935..5999 (1065 bp)
Type: Others
Protein ID: WP_011512375.1
Location: 6452..8224 (1773 bp)
Type: Others
Protein ID: WP_011512376.1
Location: 9149..9451 (303 bp)
Type: Antitoxin
Protein ID: WP_011512377.1
Location: 9453..9800 (348 bp)
Type: Toxin
Protein ID: WP_011512335.1
Location: 12606..13178 (573 bp)
Type: Others
Protein ID: Protein_13
Location: 13298..13753 (456 bp)
Type: Others
Protein ID: WP_011512339.1
Location: 13826..14272 (447 bp)
Type: Others
Protein ID: WP_011512366.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
PCRYO_RS127704248..4772-525WP_011512374.1TIGR00645 family protein-
PCRYO_RS127754935..5999-1065WP_011512375.1DUF475 domain-containing protein-
PCRYO_RS127806452..8224-1773WP_011512376.1potassium/proton antiporter-
PCRYO_RS127858397..8756+360WP_041753786.1hypothetical protein-
PCRYO_RS127909149..9451-303WP_011512377.1XRE family transcriptional regulatorAntitoxin
PCRYO_RS127959453..9800-348WP_011512335.1type II toxin-antitoxin system RelE/ParE family toxinToxin
PCRYO_RS1280010053..10649+597WP_011512336.1recombinase family protein-
PCRYO_RS1280510814..12397+1584WP_105575658.1Fic family protein-
PCRYO_RS1281012606..13178-573Protein_13recombinase family protein-
PCRYO_RS1281513298..13753-456WP_011512339.1MerR family transcriptional regulator-
PCRYO_RS1282013826..14272-447WP_011512366.1DUF2798 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..4122141221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13407.37 Da        Isoelectric Point: 7.8533

>T21563 WP_011512335.1 NC_007968:c9800-9453 [Psychrobacter cryohalolentis K5]
MWTVITTELFNQWFDQQDESTQEKVLAALVVLEQQGPSLGRPLVDTVYDSKFTNMKELRIQHRGKPLRAFFAFDPKRQAI
VLCIGDKGNRKRFYKEMLATADQQYECHLRTLGDP

Download         Length: 348 bp

>T21563 NC_007968:c9800-9453 [Psychrobacter cryohalolentis K5]
ATGTGGACTGTCATCACAACAGAGCTGTTCAACCAATGGTTTGATCAGCAAGACGAATCAACGCAAGAAAAAGTACTGGC
AGCTTTGGTGGTTTTAGAACAGCAAGGTCCAAGCTTGGGTCGCCCTTTAGTAGATACGGTGTATGATTCAAAGTTTACCA
ACATGAAAGAGTTGCGTATTCAGCACAGAGGCAAGCCACTCAGAGCCTTTTTTGCCTTTGACCCAAAGCGGCAAGCGATT
GTGCTTTGTATTGGTGATAAGGGTAATAGAAAGCGTTTTTATAAAGAAATGCTAGCCACTGCAGACCAACAGTATGAGTG
TCACCTCAGAACTTTAGGAGATCCATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11324.16 Da        Isoelectric Point: 8.5841

>AT21563 WP_011512377.1 NC_007968:c9451-9149 [Psychrobacter cryohalolentis K5]
MTKTLQEMLAERSLDSQARIKQLAEQLLLENQLSRIREELEISQKELAQTMGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT21563 NC_007968:c9451-9149 [Psychrobacter cryohalolentis K5]
ATGACTAAGACATTACAAGAGATGTTAGCTGAGCGCTCTTTGGATAGCCAAGCGCGTATTAAACAACTGGCAGAGCAACT
GCTTTTAGAAAACCAGCTGTCTCGTATCCGTGAAGAGTTAGAGATCTCTCAAAAAGAGCTGGCTCAAACCATGGGTATTA
AACAGCCTTCATTGTCTGCTATAGAAAATCGCGGCAATGATCTTAAAATATCGACCATGAAAAAATATGTTGAAGCTATG
GGTGGTAAGCTTCGTATCGATGTTGAGCTGCCAACAGGGAAGCACATAGGCTTTAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBQ1Q7U1

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1Q8E0C4

References