Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 9149..9800 Replicon plasmid 1
Accession NC_007968
Organism Psychrobacter cryohalolentis K5

Toxin (Protein)


Gene name higB Uniprot ID Q1Q7U1
Locus tag PCRYO_RS12795 Protein ID WP_011512335.1
Coordinates 9453..9800 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q1Q7U2
Locus tag PCRYO_RS12790 Protein ID WP_011512377.1
Coordinates 9149..9451 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PCRYO_RS12770 4248..4772 - 525 WP_011512374.1 TIGR00645 family protein -
PCRYO_RS12775 4935..5999 - 1065 WP_011512375.1 DUF475 domain-containing protein -
PCRYO_RS12780 6452..8224 - 1773 WP_011512376.1 potassium/proton antiporter -
PCRYO_RS12785 8397..8756 + 360 WP_041753786.1 hypothetical protein -
PCRYO_RS12790 9149..9451 - 303 WP_011512377.1 XRE family transcriptional regulator Antitoxin
PCRYO_RS12795 9453..9800 - 348 WP_011512335.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PCRYO_RS12800 10053..10649 + 597 WP_011512336.1 recombinase family protein -
PCRYO_RS12805 10814..12397 + 1584 WP_105575658.1 Fic family protein -
PCRYO_RS12810 12606..13178 - 573 Protein_13 recombinase family protein -
PCRYO_RS12815 13298..13753 - 456 WP_011512339.1 MerR family transcriptional regulator -
PCRYO_RS12820 13826..14272 - 447 WP_011512366.1 DUF2798 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..41221 41221


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(14-89)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13407.37 Da        Isoelectric Point: 7.8533

>T21563 WP_011512335.1 NC_007968:c9800-9453 [Psychrobacter cryohalolentis K5]
MWTVITTELFNQWFDQQDESTQEKVLAALVVLEQQGPSLGRPLVDTVYDSKFTNMKELRIQHRGKPLRAFFAFDPKRQAI
VLCIGDKGNRKRFYKEMLATADQQYECHLRTLGDP

Download         Length: 348 bp

>T21563 NC_007968:c9800-9453 [Psychrobacter cryohalolentis K5]
ATGTGGACTGTCATCACAACAGAGCTGTTCAACCAATGGTTTGATCAGCAAGACGAATCAACGCAAGAAAAAGTACTGGC
AGCTTTGGTGGTTTTAGAACAGCAAGGTCCAAGCTTGGGTCGCCCTTTAGTAGATACGGTGTATGATTCAAAGTTTACCA
ACATGAAAGAGTTGCGTATTCAGCACAGAGGCAAGCCACTCAGAGCCTTTTTTGCCTTTGACCCAAAGCGGCAAGCGATT
GTGCTTTGTATTGGTGATAAGGGTAATAGAAAGCGTTTTTATAAAGAAATGCTAGCCACTGCAGACCAACAGTATGAGTG
TCACCTCAGAACTTTAGGAGATCCATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11324.16 Da        Isoelectric Point: 8.5841

>AT21563 WP_011512377.1 NC_007968:c9451-9149 [Psychrobacter cryohalolentis K5]
MTKTLQEMLAERSLDSQARIKQLAEQLLLENQLSRIREELEISQKELAQTMGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT21563 NC_007968:c9451-9149 [Psychrobacter cryohalolentis K5]
ATGACTAAGACATTACAAGAGATGTTAGCTGAGCGCTCTTTGGATAGCCAAGCGCGTATTAAACAACTGGCAGAGCAACT
GCTTTTAGAAAACCAGCTGTCTCGTATCCGTGAAGAGTTAGAGATCTCTCAAAAAGAGCTGGCTCAAACCATGGGTATTA
AACAGCCTTCATTGTCTGCTATAGAAAATCGCGGCAATGATCTTAAAATATCGACCATGAAAAAATATGTTGAAGCTATG
GGTGGTAAGCTTCGTATCGATGTTGAGCTGCCAACAGGGAAGCACATAGGCTTTAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q1Q7U1

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8E0C4

References