Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2395042..2395565 Replicon chromosome
Accession NZ_CP082922
Organism Nocardioides rotundus strain MCCC 1A10561

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag K8W59_RS11865 Protein ID WP_141003302.1
Coordinates 2395042..2395302 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag K8W59_RS11870 Protein ID WP_223394072.1
Coordinates 2395305..2395565 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W59_RS11835 (K8W59_11810) 2390060..2391364 + 1305 WP_223394068.1 MFS transporter -
K8W59_RS11840 (K8W59_11815) 2391350..2391973 - 624 WP_223394070.1 arsenate reductase ArsC -
K8W59_RS11845 (K8W59_11820) 2392110..2392511 + 402 WP_141003298.1 metalloregulator ArsR/SmtB family transcription factor -
K8W59_RS11850 (K8W59_11825) 2392508..2393647 + 1140 WP_141003299.1 ACR3 family arsenite efflux transporter -
K8W59_RS11855 (K8W59_11830) 2393644..2394126 + 483 WP_141003300.1 heat-shock protein HtpX -
K8W59_RS11860 (K8W59_11835) 2394147..2394605 + 459 WP_141003301.1 low molecular weight phosphatase family protein -
K8W59_RS11865 (K8W59_11840) 2395042..2395302 - 261 WP_141003302.1 Txe/YoeB family addiction module toxin Toxin
K8W59_RS11870 (K8W59_11845) 2395305..2395565 - 261 WP_223394072.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
K8W59_RS11880 (K8W59_11855) 2396104..2399145 - 3042 WP_223394074.1 UPF0182 family protein -
K8W59_RS11885 (K8W59_11860) 2399142..2399708 - 567 WP_223394076.1 PPA1309 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10402.86 Da        Isoelectric Point: 9.7753

>T215586 WP_141003302.1 NZ_CP082922:c2395302-2395042 [Nocardioides rotundus]
MRLVWDANAWEDYLWWQTQDRKVLKRINLLIQDVVRNGNEGIGKPEPLKHDFAGYWSRRITDEHRLVYKVTSTEVRIAAC
RYHYGR

Download         Length: 261 bp

>T215586 NZ_CP110816:c3523731-3523390 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9692.83 Da        Isoelectric Point: 4.4056

>AT215586 WP_223394072.1 NZ_CP082922:c2395565-2395305 [Nocardioides rotundus]
MVKTLSYTESRARYAQVLDDVVNDREEVVITRAGHPSVVIVSLEDFESLRETAYLMRSPANARRLLDAMERLEANAGESH
DLLDAD

Download         Length: 261 bp

>AT215586 NZ_CP110816:c3524069-3523752 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References