Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5501856..5502470 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7B67_RS21785 Protein ID WP_252177943.1
Coordinates 5501856..5502149 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7B67_RS21790 Protein ID WP_256484618.1
Coordinates 5502159..5502470 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS21760 5497271..5497975 + 705 WP_252177938.1 hypothetical protein -
K7B67_RS21765 5497975..5499252 + 1278 WP_252177939.1 HlyD family type I secretion periplasmic adaptor subunit -
K7B67_RS21770 5499284..5499559 - 276 WP_252177940.1 helix-turn-helix transcriptional regulator -
K7B67_RS21775 5499556..5499909 - 354 WP_252177941.1 type II toxin-antitoxin system RelE/ParE family toxin -
K7B67_RS21780 5500132..5501607 + 1476 WP_252177942.1 C2H2-type zinc finger protein -
K7B67_RS21785 5501856..5502149 + 294 WP_252177943.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7B67_RS21790 5502159..5502470 + 312 WP_256484618.1 HigA family addiction module antitoxin Antitoxin
K7B67_RS23920 5502629..5502757 - 129 WP_256484619.1 hypothetical protein -
K7B67_RS21795 5502805..5503197 + 393 WP_252177945.1 hypothetical protein -
K7B67_RS21800 5503703..5505094 + 1392 WP_252177946.1 hypothetical protein -
K7B67_RS21805 5505175..5505753 + 579 WP_252177947.1 hypothetical protein -
K7B67_RS21810 5505821..5506018 + 198 WP_252177948.1 helix-turn-helix domain-containing protein -
K7B67_RS21815 5506015..5506824 + 810 WP_252177949.1 hypothetical protein -
K7B67_RS21820 5506817..5507074 + 258 WP_252177950.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(7-101)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11111.78 Da        Isoelectric Point: 9.7049

>T215553 WP_252177943.1 NZ_CP082909:5501856-5502149 [Endozoicomonas sp. 4G]
MIASFKDKATADIFNGKASRLARKVCPQSLWRIAARKLDQLDSVLILDELKVPPGNCLEALTRDRKGQHSIRINDQYRIC
FRWGNKGPENVEVTDYH

Download         Length: 294 bp

>T215553 NZ_CP110814:2609339-2609446 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12013.85 Da        Isoelectric Point: 8.5901

>AT215553 WP_256484618.1 NZ_CP082909:5502159-5502470 [Endozoicomonas sp. 4G]
MTRVPENRPPTHPGEMLLEEFLMPMNISQRELADAIHVPYQRVNELVNKKRGITPSTALRLARFFGMSPDFWLSLQVRWD
LYNVQTAEKSDLEKIQAFQQKTA

Download         Length: 312 bp

>AT215553 NZ_CP110814:c2609292-2609226 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References