Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2279916..2280448 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7B67_RS08865 Protein ID WP_256484812.1
Coordinates 2279916..2280119 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7B67_RS08870 Protein ID WP_252179989.1
Coordinates 2280131..2280448 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS08855 2275582..2276721 + 1140 WP_252179986.1 efflux RND transporter periplasmic adaptor subunit -
K7B67_RS08860 2276718..2279819 + 3102 WP_252179987.1 efflux RND transporter permease subunit -
K7B67_RS08865 2279916..2280119 + 204 WP_256484812.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7B67_RS08870 2280131..2280448 + 318 WP_252179989.1 HigA family addiction module antitoxin Antitoxin
K7B67_RS08875 2280473..2280997 - 525 WP_252179990.1 GNAT family N-acetyltransferase -
K7B67_RS08880 2280994..2281272 - 279 WP_252179991.1 DUF1778 domain-containing protein -
K7B67_RS08885 2281437..2282291 - 855 WP_252179992.1 EamA family transporter -
K7B67_RS08890 2282371..2282889 + 519 WP_252179993.1 MarR family transcriptional regulator -
K7B67_RS08895 2282942..2283457 + 516 WP_252179994.1 MFS transporter -
K7B67_RS08900 2283417..2284094 + 678 WP_252179995.1 MFS transporter -
K7B67_RS08905 2284232..2284537 - 306 WP_252179996.1 helix-turn-helix transcriptional regulator -
K7B67_RS08910 2284509..2284877 - 369 WP_252179997.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(8-64)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-73)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8015.23 Da        Isoelectric Point: 8.5280

>T215538 WP_256484812.1 NZ_CP082909:2279916-2280119 [Endozoicomonas sp. 4G]
VTSEGHRLISITKCLAQLNMNYSFWFEHLEGKLKIWCSIRVNKQYRLIFQWEAGEAHGLHLDPHTYR

Download         Length: 204 bp

>T215538 NZ_CP110814:c608543-608079 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11488.60 Da        Isoelectric Point: 10.0608

>AT215538 WP_252179989.1 NZ_CP082909:2280131-2280448 [Endozoicomonas sp. 4G]
MAKALKIPAHQPTSVGTMLKEEFLEPLGITQGKLAKAMGVGRKTVNELCGGRRGVTAETAFLLAKVLGTTPEFWLNLQFM
NDMWLAKHNEVLAEKLKHAYPLVAA

Download         Length: 318 bp

>AT215538 NZ_CP110814:c608878-608543 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References