Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 455474..456083 Replicon chromosome
Accession NZ_CP082909
Organism Endozoicomonas sp. 4G

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7B67_RS02200 Protein ID WP_252178738.1
Coordinates 455474..455794 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7B67_RS02205 Protein ID WP_252178739.1
Coordinates 455787..456083 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B67_RS02175 451089..451799 + 711 WP_252178733.1 DUF3581 family protein -
K7B67_RS02180 451948..453789 + 1842 WP_252178734.1 dihydroxy-acid dehydratase -
K7B67_RS02185 453841..454080 - 240 WP_252178735.1 hypothetical protein -
K7B67_RS02190 454421..454921 + 501 WP_252178736.1 hypothetical protein -
K7B67_RS02195 454971..455357 - 387 WP_252178737.1 flagellar protein FlhE -
K7B67_RS02200 455474..455794 + 321 WP_252178738.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K7B67_RS02205 455787..456083 + 297 WP_252178739.1 NadS family protein Antitoxin
K7B67_RS02210 456354..457145 - 792 WP_252178740.1 hypothetical protein -
K7B67_RS02215 457426..458727 - 1302 WP_252178741.1 ISKra4 family transposase -
K7B67_RS02220 458771..459121 - 351 WP_252178742.1 hypothetical protein -
K7B67_RS02225 459802..459966 + 165 WP_252178743.1 hypothetical protein -
K7B67_RS02230 460155..460445 + 291 WP_252178744.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-74)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12145.86 Da        Isoelectric Point: 5.1722

>T215530 WP_252178738.1 NZ_CP082909:455474-455794 [Endozoicomonas sp. 4G]
MEFVEASVFTKIITQLMSDDDYCAMQEAMIAQPDIGSVIKGTGGLRKFRWKLGDSGKRGGVRTIYYWQVSEDTFYMLYAY
TKSRQTDLTSAEKKVLSELAREFCNE

Download         Length: 321 bp

>T215530 NZ_CP110810:c11040-10741 [Pseudomonas syringae]
ATGACGACGATAAAACAGACATCTACCTATATGGCTTGGGAACGCAGGCTCAAAGACCAAAAGGCCAAAGCTGCAATTGC
CGCTCGTATTTTTAGAGTTGCAAATGGCCTGATGGGTGATGTCTCGCCAGTAGGGCAGGGCGTGAGTGAGCTACGGATAC
ACGTTGGCCCTGGTTACCGTGTTTATTTCCAGCAGCGAGGCGATGAACTGATCTTGCTGCTGTGCGGTGGTGACAAGAGC
AGCCAATCCCGAGATATCGAAACAGCAAAGAGACTGGCTGATCAATGGAGGCAAGAATGA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11192.01 Da        Isoelectric Point: 10.0112

>AT215530 WP_252178739.1 NZ_CP082909:455787-456083 [Endozoicomonas sp. 4G]
MSDHEFNFDELVESVKEAIDINKGIKKPSRSFKYEEIDVVAIRKATHLSQEKFAALIGVSIKTVQGWEQKVRKPLGPARS
LLIMFRNDPKQAMALLHQ

Download         Length: 297 bp

>AT215530 NZ_CP110810:c10744-10460 [Pseudomonas syringae]
ATGAAAGAACAAATTTTCGATTACGACCCAGCAGCAGCCCTTGACGGGCCTGAGGCAATCGCTATTTTTATCTCTGACGC
ATTTGAGACGGGGGATGCGGAGTACATCGCGAAGGCTATGGGGGTTGTCGCAAGGGCCAAAGGGATGAGCGAGCTTGCGC
GTGAGACAGGTCTTTCTCGAGAGCAGCTTTACAGATCGTTCAGTAGCAAGGGCAATCCAACCTTAAAAACCATGTTGACG
GTAATGAGAGCCCTGGGCGTGGACATGACAGCTCGAATGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References