Detailed information of TA system TA215501

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 12419..13077
• Replicon: plasmid p2018HBAB1-2
• Accession: NZ_CP082895
• Organism: Acinetobacter baumannii strain 2018HBAB1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: H1I68_RS20195
• Protein ID: WP_000312250.1
• Coordinates: 12718..13077 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H1I68_RS20190
• Protein ID: WP_001096429.1
• Coordinates: 12419..12718 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H1I68_RS20155	7586..8215	+	630	WP_002081923.1	hypothetical protein	-
H1I68_RS20160	8255..8764	+	510	WP_001043199.1	hypothetical protein	-
H1I68_RS20165	8846..9358	+	513	WP_000840065.1	hypothetical protein	-
H1I68_RS20170	9414..9743	+	330	WP_000459117.1	hypothetical protein	-
H1I68_RS20175	9780..10508	+	729	WP_001022819.1	hypothetical protein	-
H1I68_RS20645	10743..10877	+	135	WP_256349227.1	hypothetical protein	-
H1I68_RS20180	10937..11296	+	360	WP_223234021.1	hypothetical protein	-
H1I68_RS20185	11346..11882	+	537	WP_060853649.1	hypothetical protein	-
H1I68_RS20190	12419..12718	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
H1I68_RS20195	12718..13077	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H1I68_RS20200	13278..13844	+	567	WP_031948745.1	hypothetical protein	-
H1I68_RS20205	13893..14075	+	183	WP_000373384.1	hypothetical protein	-
H1I68_RS20210	14142..14840	+	699	WP_000873188.1	hypothetical protein	-
H1I68_RS20215	14979..15362	+	384	WP_000654347.1	hypothetical protein	-
H1I68_RS20220	15429..16187	+	759	WP_060853650.1	hypothetical protein	-
H1I68_RS20225	16239..16574	+	336	WP_000654055.1	hypothetical protein	-
H1I68_RS20230	17439..17753	+	315	WP_000708713.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	blaOXA-23	-	1..78023	78023

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T215501 WP_000312250.1 NZ_CP082895:c13077-12718 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T215501 NZ_CP110791:615568-615939 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGAAACCATGTCCCATCACATCGGGCGCATTACCCGTGCCTGTTATTTATCAGCGACTGCTCACTTTCCTGCTGGAGCA
CCACTACGGCCTGAGCCTCAACGATACGCCCTATCACGATGAACAGGTGATTGCACAGCAGATAGAACAAGAGATTTCCG
TGGGTGACACCATAAACACACTGGTTGAGAAATATGCATTAGTGCGAATTGGTCGTAACGGGTTCAGCGCACTGGCGCAA
GACCCGATGTTGAGCAAGGGCGATATCGTGCGGGCTCGCCAGGCTGCTGGCTTGTGGCGTGCACATTTCCCGCCCACCTT
GCTGCACCCAACCGAACCCCTAAATCCTATTCCACAGAGACCGTTAACATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT215501 WP_001096429.1 NZ_CP082895:c12718-12419 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT215501 NZ_CP110791:615936-616268 [Yersinia sp. SCPM-O-B-9106 (C-191)]
ATGAATAACCACATTACTACTTCCCCAACATGGGGCCTGAAACGTGACATTACGCCACGTTTGGGAGCCAGGCTGGTACA
GGAGGGAACACACCTGCACTTTCTGAGTGACAGAGCCAATATTGTCGGCACCTTTTCCCCTCAAGCCACTCAGGCTCTTG
ATGCGGTATTCCCCGCGCTGATAACCAAACTGGAATCGCAGCTGCTGTCCGGGGCGCTGGATCCACGCCGTCAGCAAGGC
ATTACGGTTCGGCATGGAGAATTTGTCTGTGAAGCGGATACGCTGGGCAGTCACGGTTATGTCTATATCGCGGTGTATCA
GGAACTGTCTTGA