Detailed information of TA system TA215491

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 206705..207332
• Replicon: chromosome
• Accession: NZ_CP082885
• Organism: Bartonella henselae strain FDAARGOS_1462

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A0H3M2H0
• Locus tag: K8O99_RS00925
• Protein ID: WP_011180277.1
• Coordinates: 206705..207019 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: K8O99_RS00930
• Protein ID: WP_011180278.1
• Coordinates: 207036..207332 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O99_RS00905 (K8O99_00925)	202332..203888	-	1557	WP_011180273.1	phage portal protein	-
K8O99_RS00910 (K8O99_00930)	203888..204136	-	249	WP_011180274.1	hypothetical protein	-
K8O99_RS00915 (K8O99_00935)	204140..206068	-	1929	WP_011180275.1	phage terminase large subunit family protein	-
K8O99_RS00920 (K8O99_00940)	206061..206642	-	582	WP_011180276.1	hypothetical protein	-
K8O99_RS00925 (K8O99_00945)	206705..207019	+	315	WP_011180277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8O99_RS00930 (K8O99_00950)	207036..207332	+	297	WP_011180278.1	HigA family addiction module antitoxin	Antitoxin
K8O99_RS00935 (K8O99_00955)	207742..208005	+	264	WP_011180280.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
K8O99_RS00940 (K8O99_00960)	207992..208273	+	282	WP_011180281.1	type II toxin-antitoxin system YafQ family toxin	-
K8O99_RS00945 (K8O99_00965)	208316..208594	-	279	WP_011180242.1	hypothetical protein	-
K8O99_RS00950 (K8O99_00970)	208591..209349	-	759	WP_011180282.1	phage antirepressor Ant	-
K8O99_RS00955 (K8O99_00975)	209409..209924	-	516	WP_011180283.1	phage antirepressor Ant	-
K8O99_RS00960 (K8O99_00980)	209941..210780	-	840	WP_011180284.1	antA/AntB antirepressor family protein	-
K8O99_RS00965 (K8O99_00985)	210812..211354	-	543	WP_011180285.1	phage antirepressor Ant	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	162978..232639	69661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (15-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-67)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12135.97 Da
• Isoelectric Point: 9.0878

>T215491 WP_011180277.1 NZ_CP082885:206705-207019 [Bartonella henselae]
MIHKRTNEGDLVIESFADKRCKDLLEGNPPKGFPTTLVRIVQRKLFMLDKAVDLKDLRSPPGNRLEALKGERKGQYSIRI
NDQFRICFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T215491 NZ_CP110790:c48493-48074 [Yersinia massiliensis]
ATGATCAAAAAAATATATATGCTTGATACAAATATTTGTTCTTTTATTATGCGGGAACGCCCAGCCGAAATAATTATAAA
ATTACAACAATGTATTGAGCGTCAGAATAAGATAGTGGTTTCAGCGATTACCTACTCAGAGATGCGTTTTGGCGCTATTG
GTAAGAAAGCATCACCAAAGCATACCTATCTGGTTGAAGAGTTTGTTAAACGGTTAGACGCTGTTTTACCTTGGGATGTT
GCTGCTATAGATGCAACAACGCAGATTAAGATTGCGCTGGCAAAAGCAGGAACGCCGATAGGTGGAAATGATGCCGCAAT
TGCGGGGCATGCTATTTCAACGGGTGCGATATTAGTGACTAATAATGTAAGAGAATTCGAAAGAGTTAAAAAGTTGCATA
TTGAAGACTGGGCTAATTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11262.91 Da
• Isoelectric Point: 5.8690

>AT215491 WP_011180278.1 NZ_CP082885:207036-207332 [Bartonella henselae]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSRITPDTALRLASFFDTTAEFWLNMQAAYDVSVL
QAEKADEFSKISKFECRV

Nucleotide

• Length: 297 bp

>AT215491 NZ_CP110790:c48717-48490 [Yersinia massiliensis]
ATGAGAACGGTATCTATTTTTAAAAATGGGCAAAATCGGGCAATTCGCTTACCGAAAGATATGGATTTTGAGGGGGTGAC
AGAACTGGAAATAATCAAAGATGGCGATAATATAATTTTACGCCCGATACGGCCAACGTGGGTGTCATTCATGGATGAAG
ATAAAGCAGATGATGATTTTCTTGCCGAAAGACAAGATGTTATCGAAGAGGGACGCGTCAATTTATGA

Structures

Toxin

• AlphaFold DB: A0A0H3M2H0