Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1426748..1427391 Replicon chromosome
Accession NZ_CP082857
Organism Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K8O83_RS07640 Protein ID WP_006995912.1
Coordinates 1426748..1427086 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K8O83_RS07645 Protein ID WP_006995911.1
Coordinates 1427083..1427391 (+) Length 103 a.a.

Genomic Context

K8O83_RS07610K8O83_RS07615K8O83_RS07620K8O83_RS07625K8O83_RS07630K8O83_RS07635K8O83_RS07640K8O83_RS07645K8O83_RS07660K8O83_RS07650K8O83_RS07655K8O83_RS07665K8O83_RS07670K8O83_RS07675
Location: 1422126..1422365 (240 bp)
Type: Others
Protein ID: WP_223395549.1
Location: 1422358..1422729 (372 bp)
Type: Others
Protein ID: WP_006995917.1
Location: 1422719..1422922 (204 bp)
Type: Others
Protein ID: WP_006995916.1
Location: 1422909..1423592 (684 bp)
Type: Others
Protein ID: WP_006995915.1
Location: 1423585..1423977 (393 bp)
Type: Others
Protein ID: WP_006995914.1
Location: 1423965..1426157 (2193 bp)
Type: Others
Protein ID: WP_006995913.1
Location: 1426748..1427086 (339 bp)
Type: Toxin
Protein ID: WP_006995912.1
Location: 1427083..1427391 (309 bp)
Type: Antitoxin
Protein ID: WP_006995911.1
Location: 1429101..1429763 (663 bp)
Type: Others
Protein ID: WP_006995907.1
Location: 1427722..1428241 (520 bp)
Type: Others
Protein ID: Protein_1465
Location: 1428313..1428987 (675 bp)
Type: Others
Protein ID: WP_006995908.1
Location: 1429802..1430155 (354 bp)
Type: Others
Protein ID: WP_006995906.1
Location: 1430155..1430424 (270 bp)
Type: Others
Protein ID: WP_006995905.1
Location: 1430647..1431759 (1113 bp)
Type: Others
Protein ID: WP_006995904.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
K8O83_RS076101422126..1422365+240WP_223395549.1hypothetical protein-
K8O83_RS07615 (K8O83_07520)1422358..1422729+372WP_006995917.1hypothetical protein-
K8O83_RS07620 (K8O83_07525)1422719..1422922+204WP_006995916.1hypothetical protein-
K8O83_RS07625 (K8O83_07530)1422909..1423592+684WP_006995915.1hypothetical protein-
K8O83_RS07630 (K8O83_07535)1423585..1423977+393WP_006995914.1hypothetical protein-
K8O83_RS07635 (K8O83_07540)1423965..1426157+2193WP_006995913.1DUF927 domain-containing protein-
K8O83_RS07640 (K8O83_07545)1426748..1427086+339WP_006995912.1type II toxin-antitoxin system RelE/ParE family toxinToxin
K8O83_RS07645 (K8O83_07550)1427083..1427391+309WP_006995911.1helix-turn-helix domain-containing proteinAntitoxin
K8O83_RS07650 (K8O83_07555)1427722..1428241-520Protein_1465DDE-type integrase/transposase/recombinase-
K8O83_RS07655 (K8O83_07560)1428313..1428987-675WP_006995908.1N-acylneuraminate cytidylyltransferase-
K8O83_RS07660 (K8O83_07565)1429101..1429763+663WP_006995907.1NAD(P)H-dependent oxidoreductase-
K8O83_RS07665 (K8O83_07570)1429802..1430155-354WP_006995906.1type II toxin-antitoxin system PemK/MazF family toxin-
K8O83_RS07670 (K8O83_07575)1430155..1430424-270WP_006995905.1hypothetical protein-
K8O83_RS07675 (K8O83_07580)1430647..1431759-1113WP_006995904.1iron-sulfur cluster carrier protein ApbC-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-80)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.05 Da        Isoelectric Point: 9.2488

>T215468 WP_006995912.1 NZ_CP082857:1426748-1427086 [Haemophilus aegyptius]
VKLSFIELPPFERYRKAHLSDDEYRAFQNELLENPEKGDVIQNAGGLRKIRIADSERNKGKRGGARVIYYYLIRKSQILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ

Download         Length: 339 bp

>T215468 NZ_CP110776:92993-94300 [Citrobacter freundii]
ATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGAACACTGTACCGAGATAACAAAGGGGCCATGTCATTTCA
GTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCCATTTCCATGTCACTGCCTTTGGGTCATGGCAGGATCACAG
GAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCCGACTCAGAGGCAATTATTGCCAGGATGCAGGCTAGGTTCAGA
GTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGATTGTGTTGGAGCTATCCAGCTCTATTCCCCCGA
TGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAGGCTACC
AGGAAGCGCCCCTTGGGATGGCAGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCACTGCTT
TGGTATCAGGACCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAAGATTGT
TCAAAATAACATCGATCTCAGTGAGAGTTGTGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTTTTGACG
TCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCTAAATCC
GGCGAATGGCTTCTACGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGAGTCACA
TGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGACTTGCGGCTAAGGATAGAGAGCAATTTTTCA
AGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCTGCATCG
TCATTTAGGATGACCCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCAAAAGGC
CAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCAGTACCG
CCGCCCATGTCGGGTTCCCACAAGATACCGCCGCTCAACTTATGTTCGACATGGCTACCAAGACAGAGGAGGTGGTTGCC
ACAGTAGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGCGCCATCTTCGAGGGGCTGTCCAGCCAGGCGGC
TAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11550.34 Da        Isoelectric Point: 9.9619

>AT215468 WP_006995911.1 NZ_CP082857:1427083-1427391 [Haemophilus aegyptius]
MSKLFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Download         Length: 309 bp

>AT215468 NZ_CP110776:92732-92983 [Citrobacter freundii]
ATGAAAGTGACATCTCCATCCTTGCTTGCGGCTGCGGTGCGTGACCAGCGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAGTAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References