Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 1426748..1427391 Replicon chromosome
Accession NZ_CP082857
Organism Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K8O83_RS07640 Protein ID WP_006995912.1
Coordinates 1426748..1427086 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K8O83_RS07645 Protein ID WP_006995911.1
Coordinates 1427083..1427391 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O83_RS07610 1422126..1422365 + 240 WP_223395549.1 hypothetical protein -
K8O83_RS07615 (K8O83_07520) 1422358..1422729 + 372 WP_006995917.1 hypothetical protein -
K8O83_RS07620 (K8O83_07525) 1422719..1422922 + 204 WP_006995916.1 hypothetical protein -
K8O83_RS07625 (K8O83_07530) 1422909..1423592 + 684 WP_006995915.1 hypothetical protein -
K8O83_RS07630 (K8O83_07535) 1423585..1423977 + 393 WP_006995914.1 hypothetical protein -
K8O83_RS07635 (K8O83_07540) 1423965..1426157 + 2193 WP_006995913.1 DUF927 domain-containing protein -
K8O83_RS07640 (K8O83_07545) 1426748..1427086 + 339 WP_006995912.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8O83_RS07645 (K8O83_07550) 1427083..1427391 + 309 WP_006995911.1 helix-turn-helix domain-containing protein Antitoxin
K8O83_RS07650 (K8O83_07555) 1427722..1428241 - 520 Protein_1465 DDE-type integrase/transposase/recombinase -
K8O83_RS07655 (K8O83_07560) 1428313..1428987 - 675 WP_006995908.1 N-acylneuraminate cytidylyltransferase -
K8O83_RS07660 (K8O83_07565) 1429101..1429763 + 663 WP_006995907.1 NAD(P)H-dependent oxidoreductase -
K8O83_RS07665 (K8O83_07570) 1429802..1430155 - 354 WP_006995906.1 type II toxin-antitoxin system PemK/MazF family toxin -
K8O83_RS07670 (K8O83_07575) 1430155..1430424 - 270 WP_006995905.1 hypothetical protein -
K8O83_RS07675 (K8O83_07580) 1430647..1431759 - 1113 WP_006995904.1 iron-sulfur cluster carrier protein ApbC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(11-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(40-80)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13134.05 Da        Isoelectric Point: 9.2488

>T215468 WP_006995912.1 NZ_CP082857:1426748-1427086 [Haemophilus aegyptius]
VKLSFIELPPFERYRKAHLSDDEYRAFQNELLENPEKGDVIQNAGGLRKIRIADSERNKGKRGGARVIYYYLIRKSQILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ

Download         Length: 339 bp

>T215468 NZ_CP110776:92993-94300 [Citrobacter freundii]
ATGCAGACGCTAACAGTGGCGATGAATGGTGAGGTCGTAGGAACACTGTACCGAGATAACAAAGGGGCCATGTCATTTCA
GTATGCCCCGGAGTGGATCTCGGAACCAGGTTCACGCGCCATTTCCATGTCACTGCCTTTGGGTCATGGCAGGATCACAG
GAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCCGACTCAGAGGCAATTATTGCCAGGATGCAGGCTAGGTTCAGA
GTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGATTGTGTTGGAGCTATCCAGCTCTATTCCCCCGA
TGCGGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGAAGCTCAGATTGAGCAACTGCTTGAAGGCTACC
AGGAAGCGCCCCTTGGGATGGCAGAGGATGCTGATTTTCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCACTGCTT
TGGTATCAGGACCGCTGGCAACGCCCCCTGGGCAGCACCCCAACAAGCCATATTTTTAAGCTACCCATTGGTAAGATTGT
TCAAAATAACATCGATCTCAGTGAGAGTTGTGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGTTTTGACG
TCGCCAATGCGGACCTAGCAACGTTCGGCAAGAAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCTAAATCC
GGCGAATGGCTTCTACGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGGATCGCTCCTGCGCTCAAATACGAGTCACA
TGGAGGGCCAGGTATTGCTGACGCAATGAAGTTGTTGTTGGGGTCCAGACTTGCGGCTAAGGATAGAGAGCAATTTTTCA
AGTCGCAGATCCTATTCTGGATGTTGGCCGCGATTGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCTGCATCG
TCATTTAGGATGACCCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCTGCTCAAAAGGC
CAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCAGTACCG
CCGCCCATGTCGGGTTCCCACAAGATACCGCCGCTCAACTTATGTTCGACATGGCTACCAAGACAGAGGAGGTGGTTGCC
ACAGTAGCGGCTGAGCTGCCAGCCGGTTTCCCAGAGCACATCAGTAGCGCCATCTTCGAGGGGCTGTCCAGCCAGGCGGC
TAAGATCTTGAAGGGAGTAGCCAAATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11550.34 Da        Isoelectric Point: 9.9619

>AT215468 WP_006995911.1 NZ_CP082857:1427083-1427391 [Haemophilus aegyptius]
MSKLFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Download         Length: 309 bp

>AT215468 NZ_CP110776:92732-92983 [Citrobacter freundii]
ATGAAAGTGACATCTCCATCCTTGCTTGCGGCTGCGGTGCGTGACCAGCGCAAGCTCAGCAAACTAACGCAGTCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACGACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCACTGGATCTGGAGCTTCATGTCGTGAAGCGGGGTTCAACATTGGACGATAGTAAAGTCTGGGAT
AGGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References