215466

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 289187..290535 Replicon chromosome
Accession NZ_CP082857
Organism Haemophilus aegyptius strain FDAARGOS_1478

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K8O83_RS01725 Protein ID WP_006995245.1
Coordinates 289504..290535 (+) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag K8O83_RS01720 Protein ID WP_006995246.1
Coordinates 289187..289507 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O83_RS01675 (K8O83_01640) 284410..284688 + 279 WP_006995251.1 cell division protein FtsB -
K8O83_RS01680 (K8O83_01645) 284688..285365 + 678 WP_006995250.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K8O83_RS01685 (K8O83_01650) 285362..285838 + 477 WP_006995249.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K8O83_RS01690 (K8O83_01655) 285908..286075 - 168 WP_006995248.1 hypothetical protein -
K8O83_RS01695 (K8O83_01660) 286342..286776 - 435 WP_006995247.1 D-aminoacyl-tRNA deacylase -
K8O83_RS01700 (K8O83_01665) 286773..287213 - 441 WP_005667635.1 FMN-binding protein MioC -
K8O83_RS01705 (K8O83_01670) 287310..287528 - 219 WP_005650820.1 cell division protein ZapB -
K8O83_RS01710 (K8O83_01675) 287690..288691 + 1002 WP_005672749.1 class II fructose-bisphosphatase -
K8O83_RS01715 (K8O83_01680) 288891..289199 + 309 WP_005661200.1 helix-turn-helix transcriptional regulator -
K8O83_RS01720 (K8O83_01685) 289187..289507 + 321 WP_006995246.1 HipA N-terminal domain-containing protein Antitoxin
K8O83_RS01725 (K8O83_01690) 289504..290535 + 1032 WP_006995245.1 HipA domain-containing protein Toxin
K8O83_RS01730 (K8O83_01695) 290619..292277 - 1659 WP_006995244.1 thiol reductant ABC exporter subunit CydC -
K8O83_RS01735 (K8O83_01700) 292270..294015 - 1746 WP_006995243.1 ABC transporter ATP-binding protein/permease -
K8O83_RS01740 294533..294739 + 207 WP_223395590.1 PT domain-containing protein -
K8O83_RS01745 294658..295074 + 417 Protein_317 TonB-dependent receptor plug domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39718.31 Da        Isoelectric Point: 6.5777

>T215466 WP_006995245.1 NZ_CP082857:289504-290535 [Haemophilus aegyptius]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDGHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDEQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Download         Length: 1032 bp

>T215466 NZ_CP110775:c4357678-4357337 [Citrobacter freundii]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATAGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGTAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12452.13 Da        Isoelectric Point: 6.3254

>AT215466 WP_006995246.1 NZ_CP082857:289187-289507 [Haemophilus aegyptius]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRIN
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT215466 NZ_CP110775:c4358016-4357699 [Citrobacter freundii]
ATGAGCAAAATCACATGGGGTCTGCAGCGTGATATCACGCCACGTCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATGACCGGCAAGTTCAGTGACATCGAATACCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACTGGTGAACTCAGCACCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References