215459

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 921757..923105 Replicon chromosome
Accession NZ_CP082856
Organism Haemophilus influenzae strain FDAARGOS_1479

Toxin (Protein)


Gene name HipT Uniprot ID A0A2X4XRN4
Locus tag K8P04_RS04625 Protein ID WP_005690165.1
Coordinates 921757..922788 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F9GV76
Locus tag K8P04_RS04630 Protein ID WP_005635266.1
Coordinates 922785..923105 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8P04_RS04605 917443..917850 - 408 Protein_853 TonB-dependent receptor plug domain-containing protein -
K8P04_RS04610 917798..917926 - 129 WP_223267139.1 PT domain-containing protein -
K8P04_RS04615 (K8P04_04575) 918277..920022 + 1746 WP_077643959.1 ABC transporter ATP-binding protein/permease -
K8P04_RS04620 (K8P04_04580) 920015..921673 + 1659 WP_077643960.1 thiol reductant ABC exporter subunit CydC -
K8P04_RS04625 (K8P04_04585) 921757..922788 - 1032 WP_005690165.1 HipA domain-containing protein Toxin
K8P04_RS04630 (K8P04_04590) 922785..923105 - 321 WP_005635266.1 HipA N-terminal domain-containing protein Antitoxin
K8P04_RS04635 (K8P04_04595) 923093..923401 - 309 WP_005690167.1 helix-turn-helix transcriptional regulator -
K8P04_RS04640 (K8P04_04600) 923601..924602 - 1002 WP_005690169.1 class II fructose-bisphosphatase -
K8P04_RS04645 (K8P04_04605) 924764..924982 + 219 WP_005650820.1 cell division protein ZapB -
K8P04_RS04650 (K8P04_04610) 925080..925520 + 441 WP_005667635.1 FMN-binding protein MioC -
K8P04_RS04655 (K8P04_04615) 925517..925951 + 435 WP_005690172.1 D-aminoacyl-tRNA deacylase -
K8P04_RS04660 (K8P04_04620) 926256..926732 - 477 WP_005661209.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
K8P04_RS04665 (K8P04_04625) 926729..927406 - 678 WP_077643961.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
K8P04_RS04670 (K8P04_04630) 927406..927684 - 279 WP_005661211.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39855.45 Da        Isoelectric Point: 6.5777

>T215459 WP_005690165.1 NZ_CP082856:c922788-921757 [Haemophilus influenzae]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKTMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLAFLNLLNEPEL

Download         Length: 1032 bp

>T215459 NZ_CP110775:c2405350-2404943 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12441.11 Da        Isoelectric Point: 5.9670

>AT215459 WP_005635266.1 NZ_CP082856:c923105-922785 [Haemophilus influenzae]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFAYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT215459 NZ_CP110775:c2405597-2405331 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4XRN4

Antitoxin

Source ID Structure
AlphaFold DB F9GV76

References