Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 3128..3788 Replicon plasmid unnamed2
Accession NZ_CP082854
Organism Legionella anisa strain FDAARGOS_1480

Toxin (Protein)


Gene name higB Uniprot ID A0A2Z3KTA1
Locus tag K8O89_RS19095 Protein ID WP_019232992.1
Coordinates 3128..3490 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2Z3KXZ6
Locus tag K8O89_RS19100 Protein ID WP_019232993.1
Coordinates 3483..3788 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O89_RS19075 (K8O89_18995) 533..859 + 327 WP_019232988.1 hypothetical protein -
K8O89_RS19080 (K8O89_19000) 1029..1226 + 198 WP_019232989.1 type II toxin-antitoxin system HicA family toxin -
K8O89_RS19085 (K8O89_19005) 1223..1627 + 405 WP_019232990.1 type II toxin-antitoxin system HicB family antitoxin -
K8O89_RS19090 (K8O89_19010) 1642..2964 - 1323 WP_019232991.1 DUF1186 domain-containing protein -
K8O89_RS19095 (K8O89_19015) 3128..3490 + 363 WP_019232992.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8O89_RS19100 (K8O89_19020) 3483..3788 + 306 WP_019232993.1 helix-turn-helix domain-containing protein Antitoxin
K8O89_RS19105 (K8O89_19025) 4101..4337 - 237 WP_080480132.1 hypothetical protein -
K8O89_RS19110 (K8O89_19030) 4349..4606 - 258 WP_127908205.1 hypothetical protein -
K8O89_RS19115 (K8O89_19035) 4622..4918 - 297 WP_019232994.1 hypothetical protein -
K8O89_RS19120 (K8O89_19040) 5144..7813 + 2670 WP_019232995.1 Ti-type conjugative transfer relaxase TraA -
K8O89_RS19125 (K8O89_19045) 7824..8435 + 612 WP_019232996.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..48353 48353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(47-110)

Antitoxin

Cro/C1-type helix-turn-helix domain

(41-88)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13438.39 Da        Isoelectric Point: 9.9492

>T215454 WP_019232992.1 NZ_CP082854:3128-3490 [Legionella anisa]
MKRMITIIEFPGFLSQVGNSISAAERDEFINFIARNPEVGDLIPGTGGVRKVRWGSKNKGKSGGVRVIYYFYDELAPVFL
LTAYGKGEKENLTAEQKKQISALAQVLKSECKNRRSQEHD

Download         Length: 363 bp

>T215454 NZ_CP110774:c1647700-1647098 [Acidocella sp. MX-AZ03]
ATCACCCACATTGCCAACCTGCCCTGGTTGCTGGCGAATGGCCTTCATTGTGCCAACAGTGCCGTGGTTGATCCTGATTT
CGTGGCCATCGGCAATCCTGAGCTGATCGGCAAGCGTACCCACCGAACGGTGCCGCTGCACCCCGGCGGGACGCTGGCGG
ATTATGTTCCGTTCTACTTCACCCCAAAATCGCCGATGCTCCTCAACATCAAGACGGGGCGCGGCGGGATTGCCCAGCTC
GATAACGATAAGATCGTTATTTTAGTCTCATCTTGCCAAAGCATGACCCAGAATGGCGTCACCCTCCTGTTCACGGATCG
CCATGCTTATGTTGCAACAGCCGAGTGGACCACCGACCAGAGCCGCCTGGGAGAGATAATCGACTGGGATATTCTGCGTC
GACATGACTTCGCCCGCGATGATAGCTATTTAGACAAGATGGAACGCTATCAAGCCGAAGCCCTGGCCCACCGTCACGTC
CCTCCGGGCGCGCTGCTCGGTGTCGCCTGCGCGTCGGGGAGCGCCAAGCCCATTGTGGAAGCAGCCGTCGCGGCTGCGGC
AAGCGCGGTTAAGGTATTCGTCCGCCCAGGGTGGTATTTCTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11531.14 Da        Isoelectric Point: 8.6768

>AT215454 WP_019232993.1 NZ_CP082854:3483-3788 [Legionella anisa]
MTNRNIGNEIIQGMEEAIEYIRGNKGSAKVHKVEIPNEIDVREIRENLNLSRKEFADSFGFSPRTLQHWEQGDRAPHGAA
KVLLLLLQREPATIAKILRQN

Download         Length: 306 bp

>AT215454 NZ_CP110774:c1647098-1646298 [Acidocella sp. MX-AZ03]
ATGCTCCGCTATACCCAAGGCAACCTTCTGGAATCCAGGGCCGAGGCGCTCGTGAATACCGTCAACACGGTAGGAATCAG
CGGCAAGGGCATTGCCCTGATGTTCAAGGAAGCCTACCCGGATAATTTCCGGGCCTATGAAGCCGCCTGCAAGGCCGGGC
AGCTTGAACCCGGCGGCCTGTTCATTACCGAACGCCATGACATGCTTGGCCCGCGTTACATCATCAATTTTGCCACCAAG
CAGCATTGGCGGAATCCCTCCCGCCTTGAATGGATTGAACACGGCCTCGCTGCGCTCGGGCAAGAAATCGAGGCGCGCGG
CATCCGCTCGATTGCCATCCCGCCGCTCGGTGCGGGCAATGGCGGCCTGGATTGGGCCAGGGTGAAACACTTGATCGCCG
AGTCGCTTGCCGGTCACGACTGCGAGATCATCGTTTTTGAACCGACCAAAACCTACCAAAACGTCGTTAAGCGCAATGGC
GTCGAAAAGTTGACGCCCGCCCGCGCGGCGATGGCGGAGATGATCCGGCGCTACGAGGTGCTGGGCTTCGACTGTTCGAT
GCTTGAAGCCCAGAAGCTGGCGTGGTTCCTGCACCGGGCAACCCAGCGCCTCAAATTGCCGGTTCTGATCGCTGATGATT
TTACGGCCAATCGCTATGGCCCTACTCGGATAAAGTCCGGCATCTGCTCGATAGCCTTGATGGCAGCTACATCACCTGCG
AACGGCGGGTGGCAGACGCGCGCCCGTTCGATCCGCTCCACTTCCGGCATGACCGTCAGGATCAAATCAGCGCCTACCTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2Z3KTA1

Antitoxin

Source ID Structure
AlphaFold DB A0A2Z3KXZ6

References