Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
Location | 3121810..3123047 | Replicon | chromosome |
Accession | NZ_CP082848 | ||
Organism | Legionella pneumophila strain FDAARGOS_1482 |
Toxin (Protein)
Gene name | HipT | Uniprot ID | - |
Locus tag | K8O97_RS13960 | Protein ID | WP_027224428.1 |
Coordinates | 3122115..3123047 (+) | Length | 311 a.a. |
Antitoxin (Protein)
Gene name | HipS | Uniprot ID | - |
Locus tag | K8O97_RS13955 | Protein ID | WP_027224429.1 |
Coordinates | 3121810..3122118 (+) | Length | 103 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8O97_RS13930 (K8O97_13875) | 3117496..3117693 | - | 198 | WP_014842401.1 | hypothetical protein | - |
K8O97_RS13935 (K8O97_13880) | 3117713..3118939 | - | 1227 | WP_027224432.1 | MFS transporter | - |
K8O97_RS13940 (K8O97_13885) | 3119574..3120047 | + | 474 | WP_027224431.1 | hypothetical protein | - |
K8O97_RS13945 (K8O97_13890) | 3120226..3121143 | + | 918 | WP_027224430.1 | LysR family transcriptional regulator | - |
K8O97_RS13950 (K8O97_13895) | 3121586..3121813 | + | 228 | WP_013101792.1 | helix-turn-helix transcriptional regulator | - |
K8O97_RS13955 (K8O97_13900) | 3121810..3122118 | + | 309 | WP_027224429.1 | HipA N-terminal domain-containing protein | Antitoxin |
K8O97_RS13960 (K8O97_13905) | 3122115..3123047 | + | 933 | WP_027224428.1 | HipA domain-containing protein | Toxin |
K8O97_RS13965 (K8O97_13910) | 3123176..3125743 | + | 2568 | WP_027224427.1 | magnesium-translocating P-type ATPase | - |
K8O97_RS13970 (K8O97_13915) | 3125778..3126722 | + | 945 | WP_027224426.1 | lysylphosphatidylglycerol synthase transmembrane domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 311 a.a. Molecular weight: 35780.41 Da Isoelectric Point: 9.5904
>T215450 WP_027224428.1 NZ_CP082848:3122115-3123047 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF
Download Length: 933 bp
>T215450 NZ_CP110679:3001278-3001538 [Sphingomonas sp. S6-11]
ATGTTCGAATTCGATCCGGCGAAGAGCGCGGCCAATCTGGCCAAGCATGGGATCGACTTCGAGGCTGCCCGCGCGCTTTG
GCTCGACGATCGGCGGCAGACGCCGAAGTCCGAGCGACCGGGCGAGGAAACGCGTTGGCTGGTGATCGGAATGATCCAGG
ATGTTGGCTGGACGGCAATCGTGACGCATCGAGGCGACAGAGTGCCCATCATCTCGGTGCGGCGGGCACGCAAGGAAGAG
ATGGCGCTTTATGGAAATTGA
ATGTTCGAATTCGATCCGGCGAAGAGCGCGGCCAATCTGGCCAAGCATGGGATCGACTTCGAGGCTGCCCGCGCGCTTTG
GCTCGACGATCGGCGGCAGACGCCGAAGTCCGAGCGACCGGGCGAGGAAACGCGTTGGCTGGTGATCGGAATGATCCAGG
ATGTTGGCTGGACGGCAATCGTGACGCATCGAGGCGACAGAGTGCCCATCATCTCGGTGCGGCGGGCACGCAAGGAAGAG
ATGGCGCTTTATGGAAATTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11586.38 Da Isoelectric Point: 4.5859
>AT215450 WP_027224429.1 NZ_CP082848:3121810-3122118 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR
Download Length: 309 bp
>AT215450 NZ_CP110679:3001528-3001767 [Sphingomonas sp. S6-11]
ATGGAAATTGAGAAGATCAGCTCCGAGGAACTGGACCGCCGCTTCGATGACGGCGAGGAGGTCTTGCAATATTTCGATCT
GAGCTCGGCTCGCCGCCCTGGTCTGGAGGTCCGTCGCGTGAACGTCGATTTTCCGGACTGGATGATCCGCAACCTGGACG
AGCATGCCAAGAAGCGCGGCGTCACGCGCCAGGCGCTGATCAAGATGTGGCTGGCGGACCGGCTGGAAGCCGCGGGCTGA
ATGGAAATTGAGAAGATCAGCTCCGAGGAACTGGACCGCCGCTTCGATGACGGCGAGGAGGTCTTGCAATATTTCGATCT
GAGCTCGGCTCGCCGCCCTGGTCTGGAGGTCCGTCGCGTGAACGTCGATTTTCCGGACTGGATGATCCGCAACCTGGACG
AGCATGCCAAGAAGCGCGGCGTCACGCGCCAGGCGCTGATCAAGATGTGGCTGGCGGACCGGCTGGAAGCCGCGGGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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