Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 3121810..3123047 Replicon chromosome
Accession NZ_CP082848
Organism Legionella pneumophila strain FDAARGOS_1482

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K8O97_RS13960 Protein ID WP_027224428.1
Coordinates 3122115..3123047 (+) Length 311 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag K8O97_RS13955 Protein ID WP_027224429.1
Coordinates 3121810..3122118 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O97_RS13930 (K8O97_13875) 3117496..3117693 - 198 WP_014842401.1 hypothetical protein -
K8O97_RS13935 (K8O97_13880) 3117713..3118939 - 1227 WP_027224432.1 MFS transporter -
K8O97_RS13940 (K8O97_13885) 3119574..3120047 + 474 WP_027224431.1 hypothetical protein -
K8O97_RS13945 (K8O97_13890) 3120226..3121143 + 918 WP_027224430.1 LysR family transcriptional regulator -
K8O97_RS13950 (K8O97_13895) 3121586..3121813 + 228 WP_013101792.1 helix-turn-helix transcriptional regulator -
K8O97_RS13955 (K8O97_13900) 3121810..3122118 + 309 WP_027224429.1 HipA N-terminal domain-containing protein Antitoxin
K8O97_RS13960 (K8O97_13905) 3122115..3123047 + 933 WP_027224428.1 HipA domain-containing protein Toxin
K8O97_RS13965 (K8O97_13910) 3123176..3125743 + 2568 WP_027224427.1 magnesium-translocating P-type ATPase -
K8O97_RS13970 (K8O97_13915) 3125778..3126722 + 945 WP_027224426.1 lysylphosphatidylglycerol synthase transmembrane domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(53-279)

Antitoxin

HipA, N-terminal subdomain 1

(5-98)


Sequences

Toxin        


Download         Length: 311 a.a.        Molecular weight: 35780.41 Da        Isoelectric Point: 9.5904

>T215450 WP_027224428.1 NZ_CP082848:3122115-3123047 [Legionella pneumophila]
MKRCPITYEKISDQENYSQRGLRLLSPQLKNLSPLDLSADEQRQEAIARVGKMSIQGVQKKLSAKLKIKEGSFEIVDQNG
HYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAIIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITRDRKISISPAYDLLNSTIAQKNTKEEIALPLKG
KKNNLTKSDFLNYFAVEKLGLNQNVINGIAQEFHQAIPEWRELISFSFLSQPMQEKYLQLLDQRCKRLNF

Download         Length: 933 bp

>T215450 NZ_CP110679:3001278-3001538 [Sphingomonas sp. S6-11]
ATGTTCGAATTCGATCCGGCGAAGAGCGCGGCCAATCTGGCCAAGCATGGGATCGACTTCGAGGCTGCCCGCGCGCTTTG
GCTCGACGATCGGCGGCAGACGCCGAAGTCCGAGCGACCGGGCGAGGAAACGCGTTGGCTGGTGATCGGAATGATCCAGG
ATGTTGGCTGGACGGCAATCGTGACGCATCGAGGCGACAGAGTGCCCATCATCTCGGTGCGGCGGGCACGCAAGGAAGAG
ATGGCGCTTTATGGAAATTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11586.38 Da        Isoelectric Point: 4.5859

>AT215450 WP_027224429.1 NZ_CP082848:3121810-3122118 [Legionella pneumophila]
MRKAYVSVNGIKAGILEELQSGKYQFSYFDDYHGAPVSLTMPLTNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLIIVGQDVVGAVTIEEIR

Download         Length: 309 bp

>AT215450 NZ_CP110679:3001528-3001767 [Sphingomonas sp. S6-11]
ATGGAAATTGAGAAGATCAGCTCCGAGGAACTGGACCGCCGCTTCGATGACGGCGAGGAGGTCTTGCAATATTTCGATCT
GAGCTCGGCTCGCCGCCCTGGTCTGGAGGTCCGTCGCGTGAACGTCGATTTTCCGGACTGGATGATCCGCAACCTGGACG
AGCATGCCAAGAAGCGCGGCGTCACGCGCCAGGCGCTGATCAAGATGTGGCTGGCGGACCGGCTGGAAGCCGCGGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References