Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 370554..371122 Replicon chromosome
Accession NZ_CP082848
Organism Legionella pneumophila strain FDAARGOS_1482

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K8O97_RS01635 Protein ID WP_223381005.1
Coordinates 370847..371122 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K8O97_RS01630 Protein ID WP_014844956.1
Coordinates 370554..370844 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O97_RS01610 (K8O97_01610) 365580..367067 + 1488 WP_027224504.1 lpg2912 family Dot/Icm T4SS effector -
K8O97_RS01615 (K8O97_01615) 367229..368671 - 1443 WP_027224505.1 ATP-binding protein -
K8O97_RS01620 (K8O97_01620) 368911..369804 - 894 WP_027224506.1 hypothetical protein -
K8O97_RS01625 (K8O97_01625) 370071..370262 + 192 WP_027224507.1 hypothetical protein -
K8O97_RS01630 (K8O97_01630) 370554..370844 - 291 WP_014844956.1 helix-turn-helix domain-containing protein Antitoxin
K8O97_RS01635 (K8O97_01635) 370847..371122 - 276 WP_223381005.1 hypothetical protein Toxin
K8O97_RS01640 (K8O97_01640) 371672..372175 - 504 WP_027224508.1 hypothetical protein -
K8O97_RS01645 (K8O97_01645) 372285..373331 - 1047 WP_027224509.1 FAD-dependent oxidoreductase -
K8O97_RS01650 (K8O97_01650) 373640..374602 - 963 WP_011947816.1 lytic murein transglycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10652.22 Da        Isoelectric Point: 9.6227

>T215447 WP_223381005.1 NZ_CP082848:c371122-370847 [Legionella pneumophila]
VKELLSDEEYAEFQEYLADNPLAGDVIQQTGGLRKVRWSFQGKGKRGGVRIIYYYVTPASQIRLLLIYKKGIQDDLTTDQ
KKMLRQLNERW

Download         Length: 276 bp

>T215447 NZ_CP110678:c2892481-2892089 [Sphingomonas sp. S1-29]
GTGATCGCGATCGATACGTCCGCGATCCTCGCCATTGTTCTACGCGAGCCGGAAGCCGAGACCTTTGGCGCGCTCATACA
GGCGCATAGGCGGGTATTTATCGGTGCGCCGACTTTATTCGAGTTGCGCATGGTGACGCTGGGCAAGTTTCCCGAACCGG
TTAGGGCGGCAGTAGATGCGCTGGCGCTTGCGGCACCGATCGAAACCATCGCCTTCACGGCTGAGCATCATCTTGTGGCG
CTCGATGCGTTCGACCGATACGGCAAAGGCAGGCACCCTGCGTCGCTGAATATGGGTGACTGCCTATCCTATGCCATTGC
GAAAATCGCGGATTGCCCCCTGCTTTTCAAAGGGAACGACTTCGGTCTGACCGACATTGCCCGAGTAGCCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10998.70 Da        Isoelectric Point: 8.0670

>AT215447 WP_014844956.1 NZ_CP082848:c370844-370554 [Legionella pneumophila]
MDKKLFERLYESMTQMNEIIDGERVPSREFVVDAVHVKEIRKKTGLTQEKFCHLIDVNIGTLRNWEQGRREPTGPAKALL
RAINKDPEHVLAALAG

Download         Length: 291 bp

>AT215447 NZ_CP110678:c2892732-2892478 [Sphingomonas sp. S1-29]
GTGGCCCTCAGCATCAAGGACGAAGCCACCGATCGCATGGTTCGGCACTACGCAAAGCTGAAGGGGCTCACCTACACAAG
CGCTATCCGCGTTGCCGTGACCGACGCATTGCGTCGCGAGAACGCGTTGCCCGATGAGGAAAGCTTCGTTGAGCGAATGC
GGAAAGTTCAAGACCTCGTCGCCGCACACCCGATTTTGGATGGTCGGAGCGCTGACGAGATCATCGGCTACGATGAGCAC
GGCTTGCCCGGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References