Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 1417754..1418997 | Replicon | chromosome |
| Accession | NZ_CP082847 | ||
| Organism | Legionella pneumophila strain FDAARGOS_1483 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | Q5ZSZ6 |
| Locus tag | K8P08_RS06480 | Protein ID | WP_010948074.1 |
| Coordinates | 1417754..1418692 (-) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | Q5ZSZ7 |
| Locus tag | K8P08_RS06485 | Protein ID | WP_010948073.1 |
| Coordinates | 1418689..1418997 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8P08_RS15265 | 1412917..1413048 | + | 132 | WP_015444112.1 | hypothetical protein | - |
| K8P08_RS06455 (K8P08_06515) | 1413224..1413889 | + | 666 | WP_015444114.1 | hypothetical protein | - |
| K8P08_RS06460 | 1413870..1414160 | + | 291 | WP_223804318.1 | hypothetical protein | - |
| K8P08_RS06465 (K8P08_06525) | 1414630..1415898 | - | 1269 | WP_010948076.1 | lpg2372 family Dot/Icm T4SS effector | - |
| K8P08_RS06470 (K8P08_06530) | 1416235..1416441 | + | 207 | WP_015444115.1 | hypothetical protein | - |
| K8P08_RS06475 (K8P08_06535) | 1416597..1417211 | - | 615 | WP_010948075.1 | hypothetical protein | - |
| K8P08_RS06480 (K8P08_06540) | 1417754..1418692 | - | 939 | WP_010948074.1 | lpg2370 family Dot/Icm T4SS effector | Toxin |
| K8P08_RS06485 (K8P08_06545) | 1418689..1418997 | - | 309 | WP_010948073.1 | HipA N-terminal domain-containing protein | Antitoxin |
| K8P08_RS06490 (K8P08_06550) | 1418994..1419221 | - | 228 | WP_006870829.1 | helix-turn-helix transcriptional regulator | - |
| K8P08_RS06495 (K8P08_06555) | 1420054..1420329 | + | 276 | WP_010948072.1 | helix-turn-helix domain-containing protein | - |
| K8P08_RS06500 (K8P08_06560) | 1420395..1422146 | + | 1752 | WP_010948071.1 | DUF927 domain-containing protein | - |
| K8P08_RS06505 (K8P08_06565) | 1422149..1422289 | + | 141 | WP_153802426.1 | hypothetical protein | - |
| K8P08_RS06510 (K8P08_06570) | 1422474..1422839 | + | 366 | WP_010948070.1 | TraK family protein | - |
| K8P08_RS06515 (K8P08_06575) | 1423196..1423561 | - | 366 | WP_010948069.1 | BRCT domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 1423800..1424975 | 1175 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 36077.81 Da Isoelectric Point: 8.6882
>T215446 WP_010948074.1 NZ_CP082847:c1418692-1417754 [Legionella pneumophila]
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD
MKHCPITYEKISDQENYSQRGLHLLSPQLKNLSPLDLSADEQRQEAIARVGKMSVQGVQKKLSAKLKIKEGCFEIVDQYG
QYILKPQSDIYPELPENEAITMTLAKTIGLEVPVHGLVYSKDNSLTYFIKRFDRIGHNKKLALEDFAQLSGEDRHTKYKS
SMEKVIAVIEQFCTFPKIEFVKLFKLTLFNFLVGNEDMHLKNFSLITKDRKISISPAYDLLNSTIAQKNTKEELALPLKG
KKNNLTKSDFLKYFAIEKLGLNQNVIDGIVQEFHQVIPKWQELIGFSFLSQEMQEKYLELLEQRCKRLNFFD
Download Length: 939 bp
>T215446 NZ_CP110678:2168766-2169032 [Sphingomonas sp. S1-29]
GTGAAGCTGGTCTTTTCGTCGCGCGCCTGGGACCAGTATCTCGAATGGCAGGGCGACGATCGGCGCGGGCTGGAGCGCAT
CAACGCATTGCTCAAGGAATGCATGCGCGATCCCTTTCGCGGAACCGGCAAGCCCGAGCCGCTGGGCGGCAATCTAGCCG
GCTGGTGGTCGCGCCGGATCACCCGCGAGGATCGGCTGGTGTATCGGGTTACGGGTAAGGGTGAGGGGCAGGTGCTGGAA
GTGGCGCAGTGTCGGTATCATTATTGA
GTGAAGCTGGTCTTTTCGTCGCGCGCCTGGGACCAGTATCTCGAATGGCAGGGCGACGATCGGCGCGGGCTGGAGCGCAT
CAACGCATTGCTCAAGGAATGCATGCGCGATCCCTTTCGCGGAACCGGCAAGCCCGAGCCGCTGGGCGGCAATCTAGCCG
GCTGGTGGTCGCGCCGGATCACCCGCGAGGATCGGCTGGTGTATCGGGTTACGGGTAAGGGTGAGGGGCAGGTGCTGGAA
GTGGCGCAGTGTCGGTATCATTATTGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11557.38 Da Isoelectric Point: 4.5994
>AT215446 WP_010948073.1 NZ_CP082847:c1418997-1418689 [Legionella pneumophila]
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR
MRKAYVSVSGIKAGILEELQGGTYQFTYFEDYHGAPVSLTMPLKNKVYDFDVFPPFFEGLLPEGIMLEALLRKYKIDKND
YFGQLILVGQDVVGAVTIEEIR
Download Length: 309 bp
>AT215446 NZ_CP110678:2168497-2168769 [Sphingomonas sp. S1-29]
ATGGCGTACATTGTCGACATGGAAAGCCTGAGCATCTCCGAAGCGCGCGCCAATATGAAGGCGGTGGTCGATCGCGTCGT
GGCCGACAAGGCACCGGTGGCGATCACCCGCCAGCGCGGCGAGGGCGTGGTGATGATCTCGGCGAGCGAATGGGCGTCGA
TCGAGGAAACATTGTACCTGCTGCAGTCGCCGGCGAACGCGCGCGCGCTGATCGAATCGATCGCCGAGCTGGACGCCGGC
AAGGGTAGCGAGCGCGACCTGATCGCGCCGTGA
ATGGCGTACATTGTCGACATGGAAAGCCTGAGCATCTCCGAAGCGCGCGCCAATATGAAGGCGGTGGTCGATCGCGTCGT
GGCCGACAAGGCACCGGTGGCGATCACCCGCCAGCGCGGCGAGGGCGTGGTGATGATCTCGGCGAGCGAATGGGCGTCGA
TCGAGGAAACATTGTACCTGCTGCAGTCGCCGGCGAACGCGCGCGCGCTGATCGAATCGATCGCCGAGCTGGACGCCGGC
AAGGGTAGCGAGCGCGACCTGATCGCGCCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|