Detailed information of TA system TA215424

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2149627..2149869
• Replicon: chromosome
• Accession: NZ_CP082841
• Organism: Kluyvera sp. CRP

Toxin (Protein)

• Gene name: hokX
• Uniprot ID: -
• Locus tag: K7B04_RS10120
• Protein ID: WP_223803940.1
• Coordinates: 2149717..2149869 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokX
Locus tag	-
Coordinates	2149627..2149677 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K7B04_RS10095 (K7B04_10065)	2145583..2146575	+	993	WP_106926080.1	RNA polymerase sigma factor RpoS	-
K7B04_RS10100 (K7B04_10070)	2146637..2147041	-	405	WP_064543127.1	MarR family transcriptional regulator	-
K7B04_RS10105 (K7B04_10075)	2147193..2147786	+	594	WP_163446285.1	non-oxidative hydroxyarylic acid decarboxylases subunit B	-
K7B04_RS10110 (K7B04_10080)	2147786..2149213	+	1428	WP_064543132.1	non-oxidative hydroxyarylic acid decarboxylases subunit C	-
K7B04_RS10115 (K7B04_10085)	2149224..2149460	+	237	WP_065357919.1	non-oxidative hydroxyarylic acid decarboxylases subunit D	-
-	2149627..2149677	-	51	-	-	Antitoxin
K7B04_RS10120 (K7B04_10090)	2149717..2149869	+	153	WP_223803940.1	Hok/Gef family protein	Toxin
K7B04_RS10125 (K7B04_10095)	2149981..2152542	-	2562	WP_223803941.1	DNA mismatch repair protein MutS	-
K7B04_RS10130 (K7B04_10100)	2152760..2154043	+	1284	WP_223803942.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5584.78 Da
• Isoelectric Point: 7.8276

>T215424 WP_223803940.1 NZ_CP082841:2149717-2149869 [Kluyvera sp. CRP]
MLTKYALVAIIVLCATALGFTLLVRDSLCELSIHERGMEFKAILAYEPKK

Nucleotide

• Length: 153 bp

>T215424 NZ_CP110674:c2885249-2884893 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin

Nucleotide

• Length: 51 bp

>AT215424 NZ_CP082841:c2149677-2149627 [Kluyvera sp. CRP]
GTTCGGGTTCGATGCTAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTT

Structures

Antitoxin