Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1789015..1789742 Replicon chromosome
Accession NZ_CP082841
Organism Kluyvera sp. CRP

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K7B04_RS08430 Protein ID WP_163447850.1
Coordinates 1789015..1789329 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7B04_RS08435 Protein ID WP_163447851.1
Coordinates 1789326..1789742 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7B04_RS08410 (K7B04_08380) 1784781..1785749 - 969 WP_163447847.1 TerC family protein -
K7B04_RS08415 (K7B04_08385) 1786018..1786995 - 978 WP_163447848.1 Gfo/Idh/MocA family oxidoreductase -
K7B04_RS08420 (K7B04_08390) 1787068..1787568 - 501 WP_064542149.1 M48 family metallopeptidase -
K7B04_RS08425 (K7B04_08395) 1787652..1788788 + 1137 WP_163447849.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
K7B04_RS08430 (K7B04_08400) 1789015..1789329 + 315 WP_163447850.1 type II toxin-antitoxin system HigB family toxin Toxin
K7B04_RS08435 (K7B04_08405) 1789326..1789742 + 417 WP_163447851.1 helix-turn-helix domain-containing protein Antitoxin
K7B04_RS08440 (K7B04_08410) 1789755..1791773 - 2019 WP_163447852.1 NADPH-dependent 2,4-dienoyl-CoA reductase -
K7B04_RS08445 (K7B04_08415) 1791912..1792982 - 1071 WP_223803810.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
K7B04_RS08450 (K7B04_08420) 1792979..1794367 - 1389 WP_223803811.1 phosphomannomutase CpsG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Antitoxin HigA

(1-138)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12068.18 Da        Isoelectric Point: 10.3934

>T215422 WP_163447850.1 NZ_CP082841:1789015-1789329 [Kluyvera sp. CRP]
MHLITLKALKDAGDKFPQHKTELVALGNVLAKGYFRTPTALKAVFPSLDNFKYLDKHYVINIGRNELRVVAMLFFETQKC
YIRHVFTHKEYDIFTAAHRTKGKK

Download         Length: 315 bp

>T215422 NZ_CP110674:c2750027-2749704 [Mycobacterium tuberculosis]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15041.41 Da        Isoelectric Point: 4.5392

>AT215422 WP_163447851.1 NZ_CP082841:1789326-1789742 [Kluyvera sp. CRP]
MMVIADILKAGEKLTAVAPFLAGIQNDEQYAEALAFVDHLLLNDPDNPLLDLVCAKISAWENASPEFAEFNAQRDVMPAG
LSVIRTLMDQYGLTLSDLPEIGSKSMVSRVLNGQRKLTLDHAKKLAARFGISPALFID

Download         Length: 417 bp

>AT215422 NZ_CP110674:c2750352-2750107 [Mycobacterium tuberculosis]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References