Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 139365..139936 Replicon plasmid 2
Accession NC_007950
Organism Polaromonas sp. JS666

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag BPRO_RS26895 Protein ID WP_041390650.1
Coordinates 139658..139936 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag BPRO_RS26890 Protein ID WP_011486214.1
Coordinates 139365..139649 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BPRO_RS30285 135262..135759 - 498 WP_011486207.1 hypothetical protein -
BPRO_RS29355 136026..136559 - 534 WP_157046066.1 hypothetical protein -
BPRO_RS26870 136581..137282 - 702 WP_011486209.1 toll/interleukin-1 receptor domain-containing protein -
BPRO_RS26875 137387..137947 - 561 WP_011486210.1 hypothetical protein -
BPRO_RS29130 137954..138436 - 483 WP_157046067.1 hypothetical protein -
BPRO_RS29135 138454..138855 - 402 WP_157046068.1 hypothetical protein -
BPRO_RS26885 139126..139368 - 243 WP_011486213.1 hypothetical protein -
BPRO_RS26890 139365..139649 - 285 WP_011486214.1 HigA family addiction module antidote protein Antitoxin
BPRO_RS26895 139658..139936 - 279 WP_041390650.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BPRO_RS26900 139968..140654 - 687 WP_011486216.1 site-specific integrase -
BPRO_RS28270 140680..141825 + 1146 WP_157046069.1 hypothetical protein -
BPRO_RS26910 141904..142677 - 774 WP_011486218.1 Crp/Fnr family transcriptional regulator -
BPRO_RS29140 142780..143016 - 237 WP_198141073.1 site-specific integrase -
BPRO_RS30290 142935..143513 - 579 WP_198141074.1 hypothetical protein -
BPRO_RS26920 143888..144388 + 501 WP_041390654.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..338007 338007


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(4-80)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10369.91 Da        Isoelectric Point: 9.6891

>T21542 WP_041390650.1 NC_007950:c139936-139658 [Polaromonas sp. JS666]
MIKNFRHKGLQRFFESGSKAGIQAAHAPKLRLQLAALDQAIKPEDLSAPAWSLHPLKGDLKGHWAVTVNGNWRLVFCFEG
TDAVLVDYRDYH

Download         Length: 279 bp

>T21542 NC_007950:c139936-139658 [Polaromonas sp. JS666]
ATGATCAAGAATTTTCGACACAAGGGGTTGCAGCGCTTTTTCGAGAGCGGTAGCAAGGCTGGAATACAAGCAGCCCATGC
GCCCAAACTGCGCCTCCAATTAGCCGCTCTTGACCAGGCGATAAAGCCGGAAGACCTTTCCGCCCCGGCCTGGTCTTTGC
ACCCGCTGAAAGGCGATTTAAAGGGGCATTGGGCAGTGACCGTCAACGGAAACTGGCGATTAGTCTTTTGTTTTGAGGGC
ACAGACGCGGTGCTCGTTGATTACCGCGATTACCACTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10429.05 Da        Isoelectric Point: 9.9342

>AT21542 WP_011486214.1 NC_007950:c139649-139365 [Polaromonas sp. JS666]
MTRMHNPPHPGEVLREYLGEITVTEAALQLGVNRVTLSRVVTGSSGISPDMAYRLGDAFGTSAELWAGMQMQYDLYQAGK
MKRPKIRRMAAQFA

Download         Length: 285 bp

>AT21542 NC_007950:c139649-139365 [Polaromonas sp. JS666]
ATGACTCGCATGCACAATCCGCCGCACCCAGGCGAAGTCCTTCGGGAGTATTTGGGTGAAATTACTGTGACTGAGGCCGC
TTTGCAGTTGGGTGTAAACCGGGTCACGCTCTCCCGCGTGGTGACGGGATCGTCTGGAATTTCCCCTGACATGGCTTATC
GGCTGGGCGATGCCTTTGGCACCAGTGCTGAACTGTGGGCCGGTATGCAGATGCAGTACGACCTCTACCAGGCAGGAAAG
ATGAAGCGCCCGAAGATTCGCCGGATGGCAGCTCAATTCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References