215395

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5464347..5464759 Replicon chromosome
Accession NZ_CP082835
Organism Escherichia coli strain 1613

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag K8O78_RS27225 Protein ID WP_000132630.1
Coordinates 5464347..5464688 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5464683..5464759 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O78_RS27205 (5460358) 5460358..5461770 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
K8O78_RS27210 (5461947) 5461947..5462111 + 165 WP_000394274.1 DUF1127 domain-containing protein -
K8O78_RS27215 (5462208) 5462208..5463089 + 882 WP_001304007.1 DUF262 domain-containing protein -
K8O78_RS27220 (5463137) 5463137..5464300 + 1164 WP_001304006.1 DUF1524 domain-containing protein -
K8O78_RS27225 (5464347) 5464347..5464688 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- (5464683) 5464683..5464759 + 77 NuclAT_14 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_14 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_14 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_14 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_15 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_15 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_15 - Antitoxin
- (5464683) 5464683..5464759 + 77 NuclAT_15 - Antitoxin
K8O78_RS27230 (5464909) 5464909..5466663 - 1755 WP_000110094.1 restriction endonuclease subunit S -
K8O78_RS27235 (5466663) 5466663..5468132 - 1470 WP_263752189.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5453840..5472560 18720


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T215395 WP_000132630.1 NZ_CP082835:c5464688-5464347 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T215395 NZ_CP110674:701793-702194 [Mycobacterium tuberculosis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 77 bp

>AT215395 NZ_CP082835:5464683-5464759 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References