Detailed information of TA system TA215391

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4466321..4466542
• Replicon: chromosome
• Accession: NZ_CP082835
• Organism: Escherichia coli strain 1613

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: K8O78_RS22495
• Protein ID: WP_001295224.1
• Coordinates: 4466321..4466428 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4466477..4466542 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O78_RS22470 (4461574)	4461574..4462326	-	753	Protein_4398	cellulose biosynthesis protein BcsQ	-
K8O78_RS22475 (4462338)	4462338..4462526	-	189	WP_001063316.1	cellulose biosynthesis protein BcsR	-
K8O78_RS22480 (4462799)	4462799..4464370	+	1572	WP_001204925.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
K8O78_RS22485 (4464367)	4464367..4464558	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
K8O78_RS22490 (4464555)	4464555..4466234	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
K8O78_RS22495 (4466321)	4466321..4466428	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
- (4466477)	4466477..4466542	+	66	NuclAT_16	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_16	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_16	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_16	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_21	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_21	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_21	-	Antitoxin
- (4466477)	4466477..4466542	+	66	NuclAT_21	-	Antitoxin
K8O78_RS22500 (4466904)	4466904..4468175	+	1272	WP_001301684.1	aromatic amino acid transport family protein	-
K8O78_RS22505 (4468205)	4468205..4469209	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
K8O78_RS22510 (4469206)	4469206..4470189	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
K8O78_RS22515 (4470200)	4470200..4471102	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T215391 WP_001295224.1 NZ_CP082835:c4466428-4466321 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T215391 NZ_CP110674:c638962-638549 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Nucleotide

• Length: 66 bp

>AT215391 NZ_CP082835:4466477-4466542 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin