Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2172003..2172474 | Replicon | chromosome |
| Accession | NZ_CP082835 | ||
| Organism | Escherichia coli strain 1613 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | K8O78_RS10840 | Protein ID | WP_001303511.1 |
| Coordinates | 2172196..2172474 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | K8O78_RS10835 | Protein ID | WP_001302048.1 |
| Coordinates | 2172003..2172194 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8O78_RS10795 (2167210) | 2167210..2167794 | - | 585 | WP_000206793.1 | DUF551 domain-containing protein | - |
| K8O78_RS10800 (2167851) | 2167851..2168246 | - | 396 | WP_001118159.1 | DUF977 family protein | - |
| K8O78_RS10805 (2168262) | 2168262..2169031 | - | 770 | Protein_2118 | DUF1627 domain-containing protein | - |
| K8O78_RS10810 (2169057) | 2169057..2169797 | - | 741 | WP_000788938.1 | ATP-binding protein | - |
| K8O78_RS10815 (2169804) | 2169804..2170766 | - | 963 | WP_000095669.1 | helix-turn-helix domain-containing protein | - |
| K8O78_RS10820 (2170789) | 2170789..2171214 | - | 426 | WP_000693943.1 | toxin YdaT family protein | - |
| K8O78_RS10825 (2171211) | 2171211..2171513 | - | 303 | WP_000172738.1 | transcriptional regulator | - |
| K8O78_RS10830 (2171611) | 2171611..2171982 | + | 372 | WP_001169686.1 | hypothetical protein | - |
| K8O78_RS10835 (2172003) | 2172003..2172194 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| K8O78_RS10840 (2172196) | 2172196..2172474 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K8O78_RS10845 (2172827) | 2172827..2173126 | + | 300 | WP_072143447.1 | hypothetical protein | - |
| K8O78_RS10850 (2173198) | 2173198..2173416 | + | 219 | WP_001171930.1 | protein YdfC | - |
| K8O78_RS10855 (2173985) | 2173985..2174173 | + | 189 | WP_000449192.1 | cell division inhibition protein DicB | - |
| K8O78_RS10860 (2174170) | 2174170..2174361 | + | 192 | WP_001090200.1 | DUF1482 family protein | - |
| K8O78_RS10865 (2174454) | 2174454..2176925 | + | 2472 | WP_000048458.1 | exonuclease | - |
| K8O78_RS10870 (2176998) | 2176998..2177249 | + | 252 | WP_000005552.1 | excisionase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | Prophage | - | nleG7' | 2081662..2180761 | 99099 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T215375 WP_001303511.1 NZ_CP082835:2172196-2172474 [Escherichia coli]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T215375 NZ_CP110664:c1805672-1805205 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGATAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTATTAATGTTAAAACTCTAA
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGATAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTATTAATGTTAAAACTCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT215375 WP_001302048.1 NZ_CP082835:2172003-2172194 [Escherichia coli]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT215375 NZ_CP110664:c1805936-1805676 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGTATTTTAGGTAA
GACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACTGTTTTCCAATTAA
ATGAGCAGGCTTTTGAGCAATTTAACCGATTACTAGAACAACCGACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGTATTTTAGGTAA
GACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACTGTTTTCCAATTAA
ATGAGCAGGCTTTTGAGCAATTTAACCGATTACTAGAACAACCGACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|