Detailed information of TA system TA215367

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1277402..1277627
• Replicon: chromosome
• Accession: NZ_CP082835
• Organism: Escherichia coli strain 1613

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: K8O78_RS05920
• Protein ID: WP_000813263.1
• Coordinates: 1277472..1277627 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1277402..1277460 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8O78_RS05890	1272677..1273768	+	1092	WP_001205823.1	hypothetical protein	-
K8O78_RS05895	1273775..1274521	+	747	WP_000788751.1	ATP-binding protein	-
K8O78_RS05900	1274543..1275313	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
K8O78_RS05905	1275329..1275742	+	414	WP_001151233.1	DUF977 family protein	-
K8O78_RS05910	1276094..1276867	-	774	WP_000160654.1	alpha/beta hydrolase	-
K8O78_RS05915	1277129..1277212	+	84	Protein_1157	ORF6N domain-containing protein	-
-	1277402..1277460	-	59	-	-	Antitoxin
K8O78_RS05920	1277472..1277627	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
K8O78_RS05925	1277795..1278073	+	279	WP_001341388.1	hypothetical protein	-
K8O78_RS05930	1278075..1279124	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
K8O78_RS05935	1279137..1279508	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
K8O78_RS05940	1279498..1279869	+	372	WP_000090264.1	antiterminator Q family protein	-
K8O78_RS05945	1280021..1280839	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
K8O78_RS05950	1281126..1281322	+	197	Protein_1164	TrmB family transcriptional regulator	-
K8O78_RS05955	1281460..1282173	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T215367 WP_000813263.1 NZ_CP082835:1277472-1277627 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T215367 NZ_CP110661:4603551-4604468 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT215367 NZ_CP082835:c1277460-1277402 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin