Detailed information of TA system TA215288

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4295626..4295884
• Replicon: chromosome
• Accession: NZ_CP082827
• Organism: Escherichia coli strain SCAID WND2-2021 (3/145)

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: K8B73_RS20695
• Protein ID: WP_000809168.1
• Coordinates: 4295732..4295884 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4295626..4295683 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B73_RS20680	4292018..4292977	+	960	WP_000871674.1	hypothetical protein	-
K8B73_RS20685	4293015..4293914	-	900	WP_001300855.1	transcriptional activator NhaR	-
K8B73_RS20690	4293980..4295146	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4295626..4295683	-	58	-	-	Antitoxin
K8B73_RS20695	4295732..4295884	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
K8B73_RS20700	4295988..4297118	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
K8B73_RS20705	4297207..4299123	-	1917	WP_000516135.1	molecular chaperone DnaK	-
K8B73_RS20710	4299499..4299903	+	405	WP_000843584.1	DUF2541 family protein	-
K8B73_RS20715	4299929..4300642	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T215288 WP_000809168.1 NZ_CP082827:4295732-4295884 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T215288 NZ_CP110619:3554177-3554521 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT215288 NZ_CP082827:c4295683-4295626 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin