Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 740476..741169 Replicon chromosome
Accession NZ_CP082827
Organism Escherichia coli strain SCAID WND2-2021 (3/145)

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K8B73_RS03590 Protein ID WP_000415584.1
Coordinates 740476..740772 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K8B73_RS03595 Protein ID WP_000650107.1
Coordinates 740774..741169 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B73_RS03555 (735555) 735555..735869 - 315 WP_000958598.1 putative quinol monooxygenase -
K8B73_RS03560 (735900) 735900..736481 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K8B73_RS03565 (736809) 736809..737141 + 333 WP_000917684.1 DUF2645 family protein -
K8B73_RS03570 (737187) 737187..738536 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K8B73_RS03575 (738533) 738533..739192 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K8B73_RS03580 (739344) 739344..739736 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K8B73_RS03585 (739789) 739789..740271 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K8B73_RS03590 (740476) 740476..740772 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K8B73_RS03595 (740774) 740774..741169 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K8B73_RS03600 (741302) 741302..742909 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K8B73_RS03605 (743047) 743047..745305 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T215269 WP_000415584.1 NZ_CP082827:740476-740772 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T215269 NZ_CP110619:c2236222-2235878 [Mycobacterium tuberculosis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT215269 WP_000650107.1 NZ_CP082827:740774-741169 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT215269 NZ_CP110619:c2236464-2236216 [Mycobacterium tuberculosis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References