Detailed information of TA system TA215250

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4225287..4225545
• Replicon: chromosome
• Accession: NZ_CP082824
• Organism: Escherichia coli strain SCAID URN1-2021 (19/278)

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: K8B79_RS20665
• Protein ID: WP_000809168.1
• Coordinates: 4225393..4225545 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4225287..4225344 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B79_RS20650	4221116..4222375	-	1260	WP_000494929.1	hypothetical protein	-
K8B79_RS20655	4222504..4223997	-	1494	WP_219079086.1	sulfatase-like hydrolase/transferase	-
K8B79_RS20660	4224017..4224778	-	762	WP_001274832.1	outer membrane protein OmpK	-
-	4225287..4225344	-	58	-	-	Antitoxin
K8B79_RS20665	4225393..4225545	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
K8B79_RS20670	4225650..4226780	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
K8B79_RS20675	4226869..4228785	-	1917	WP_000516135.1	molecular chaperone DnaK	-
K8B79_RS20680	4229157..4229561	+	405	WP_000843687.1	DUF2541 family protein	-
K8B79_RS20685	4229587..4230300	+	714	WP_001102391.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T215250 WP_000809168.1 NZ_CP082824:4225393-4225545 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T215250 NZ_CP110619:c755775-755338 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT215250 NZ_CP082824:c4225344-4225287 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin