Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 737369..738062 Replicon chromosome
Accession NZ_CP082824
Organism Escherichia coli strain SCAID URN1-2021 (19/278)

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K8B79_RS03575 Protein ID WP_000415584.1
Coordinates 737369..737665 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K8B79_RS03580 Protein ID WP_000650107.1
Coordinates 737667..738062 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B79_RS03540 (732457) 732457..732771 - 315 WP_000958598.1 putative quinol monooxygenase -
K8B79_RS03545 (732802) 732802..733383 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K8B79_RS03550 (733702) 733702..734034 + 333 WP_000917685.1 DUF2645 family protein -
K8B79_RS03555 (734080) 734080..735429 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K8B79_RS03560 (735426) 735426..736085 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K8B79_RS03565 (736237) 736237..736629 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K8B79_RS03570 (736682) 736682..737164 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K8B79_RS03575 (737369) 737369..737665 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K8B79_RS03580 (737667) 737667..738062 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K8B79_RS03585 (738195) 738195..739802 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K8B79_RS03590 (739940) 739940..742198 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T215232 WP_000415584.1 NZ_CP082824:737369-737665 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T215232 NZ_CP110615:c3594436-3594068 [Rhodococcus sp. 75]
GTGAGCGTGCTCGTCGACACCTCGGTGTGGGTGGACCACCTCCGGACCGGCAACCCGCGCCTGGCGGCCCTGCTCGAGCA
GTCCCGGGTCCTCATCCACCCCTGGGTGCTTGGTGAGCTCGCACTGGGTGGGGTCATCCGGAACGCGGAGGTGTCGACAC
TGCTCGGGGCGCTGCCGCGAGCACCCCTGGTCTCAGACTCGGAGCTCGTGGGGTTCATCCAGACCCAGGCGCTGCACGGG
CGCGGAGTCGGGTACGTCGATGCCCAGCTCCTCGCCTCCACCGTCCTGGACCCTGACGCCGTGCTGTGGAGCGCCGACAA
GGGGCTCAGCGCCGCCGCTGCCGAGCTCGGCGTGGCTCACCAGACCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT215232 WP_000650107.1 NZ_CP082824:737667-738062 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT215232 NZ_CP110615:c3594627-3594433 [Rhodococcus sp. 75]
ATGCGCACCACAATCGCCCTGGACGACGATCTCGTGGCGGAGGCTCAGCGACTCACCGGCACCACCGAGAAGGCGGCGCT
CGTGCGCGAGGCCCTGACCGCCCTCATCGAGCGGGAGAGTGCGCATCGGCTCGCCCGTCTGGGGGGGACCATGCCGGAGC
TGCAGATCGCACCCCGTCGACGCACCGCCCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References