Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6099349..6099944 Replicon chromosome
Accession NZ_CP082821
Organism Pseudomonas aeruginosa strain SCAID PLC1-2021 (16/222)

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag K8B72_RS29545 Protein ID WP_003113526.1
Coordinates 6099666..6099944 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K8B72_RS29540 Protein ID WP_003133769.1
Coordinates 6099349..6099654 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B72_RS29520 (K8B72_29520) 6094739..6095329 + 591 WP_071536478.1 SLATT domain-containing protein -
K8B72_RS29525 (K8B72_29525) 6095326..6096591 + 1266 WP_023094906.1 nucleotidyltransferase -
K8B72_RS29530 (K8B72_29530) 6096675..6097574 - 900 WP_225932746.1 hypothetical protein -
K8B72_RS29540 (K8B72_29540) 6099349..6099654 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
K8B72_RS29545 (K8B72_29545) 6099666..6099944 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8B72_RS34385 6099997..6100125 - 129 Protein_5854 integrase -
K8B72_RS29550 (K8B72_29550) 6100273..6102501 + 2229 WP_003133778.1 TonB-dependent receptor -
K8B72_RS29555 (K8B72_29555) 6102572..6103219 - 648 WP_003095021.1 carbonate dehydratase -
K8B72_RS29560 (K8B72_29560) 6103281..6104519 - 1239 WP_003095023.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T215210 WP_003113526.1 NZ_CP082821:c6099944-6099666 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T215210 NZ_CP110534:c253796-253494 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAACAATGTATCCCAATGGCAGGAGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT215210 WP_003133769.1 NZ_CP082821:c6099654-6099349 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT215210 NZ_CP110534:c253487-253200 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTATGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACGCTCAAACACGCCGGGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References