Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
Location | 6099349..6099944 | Replicon | chromosome |
Accession | NZ_CP082821 | ||
Organism | Pseudomonas aeruginosa strain SCAID PLC1-2021 (16/222) |
Toxin (Protein)
Gene name | higB | Uniprot ID | V6ALY3 |
Locus tag | K8B72_RS29545 | Protein ID | WP_003113526.1 |
Coordinates | 6099666..6099944 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | K8B72_RS29540 | Protein ID | WP_003133769.1 |
Coordinates | 6099349..6099654 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K8B72_RS29520 (K8B72_29520) | 6094739..6095329 | + | 591 | WP_071536478.1 | SLATT domain-containing protein | - |
K8B72_RS29525 (K8B72_29525) | 6095326..6096591 | + | 1266 | WP_023094906.1 | nucleotidyltransferase | - |
K8B72_RS29530 (K8B72_29530) | 6096675..6097574 | - | 900 | WP_225932746.1 | hypothetical protein | - |
K8B72_RS29540 (K8B72_29540) | 6099349..6099654 | - | 306 | WP_003133769.1 | HigA family addiction module antitoxin | Antitoxin |
K8B72_RS29545 (K8B72_29545) | 6099666..6099944 | - | 279 | WP_003113526.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K8B72_RS34385 | 6099997..6100125 | - | 129 | Protein_5854 | integrase | - |
K8B72_RS29550 (K8B72_29550) | 6100273..6102501 | + | 2229 | WP_003133778.1 | TonB-dependent receptor | - |
K8B72_RS29555 (K8B72_29555) | 6102572..6103219 | - | 648 | WP_003095021.1 | carbonate dehydratase | - |
K8B72_RS29560 (K8B72_29560) | 6103281..6104519 | - | 1239 | WP_003095023.1 | C69 family dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10646.19 Da Isoelectric Point: 7.8937
>T215210 WP_003113526.1 NZ_CP082821:c6099944-6099666 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T215210 NZ_CP110534:c253796-253494 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAACAATGTATCCCAATGGCAGGAGTGA
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCC
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAACAATGTATCCCAATGGCAGGAGTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11214.73 Da Isoelectric Point: 4.6081
>AT215210 WP_003133769.1 NZ_CP082821:c6099654-6099349 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG
Download Length: 306 bp
>AT215210 NZ_CP110534:c253487-253200 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTATGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACGCTCAAACACGCCGGGGATTAA
ATGCATAAATTAACACCTTATGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAAAACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACGCTCAAACACGCCGGGGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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