Detailed information of TA system TA215195

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2581355..2581539
• Replicon: chromosome
• Accession: NZ_CP082815
• Organism: Staphylococcus aureus strain SCAID WND1-2021 (598)

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: K8B78_RS12920
• Protein ID: WP_000482647.1
• Coordinates: 2581432..2581539 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2581355..2581415 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B78_RS12905	2576865..2577032	-	168	Protein_2517	hypothetical protein	-
K8B78_RS12910	2577263..2578996	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
K8B78_RS12915	2579021..2580784	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2581355..2581415	+	61	-	-	Antitoxin
K8B78_RS12920	2581432..2581539	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
K8B78_RS12925	2581673..2582059	-	387	WP_000779351.1	flippase GtxA	-
K8B78_RS12930	2582327..2583469	+	1143	WP_001176855.1	glycerate kinase	-
K8B78_RS12935	2583529..2584188	+	660	WP_000831298.1	membrane protein	-
K8B78_RS12940	2584370..2585581	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
K8B78_RS12945	2585704..2586177	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T215195 WP_000482647.1 NZ_CP082815:c2581539-2581432 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T215195 NZ_CP110532:c251796-251494 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCT
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT215195 NZ_CP082815:2581355-2581415 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin