Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2122244..2122667 | Replicon | chromosome |
| Accession | NZ_CP082815 | ||
| Organism | Staphylococcus aureus strain SCAID WND1-2021 (598) | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5S9I4Y6 |
| Locus tag | K8B78_RS10475 | Protein ID | WP_001065091.1 |
| Coordinates | 2122416..2122667 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0E0VQM8 |
| Locus tag | K8B78_RS10470 | Protein ID | WP_000028422.1 |
| Coordinates | 2122244..2122426 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B78_RS10425 (2117630) | 2117630..2119291 | - | 1662 | WP_000625088.1 | terminase large subunit | - |
| K8B78_RS10430 (2119288) | 2119288..2119632 | - | 345 | WP_000402904.1 | hypothetical protein | - |
| K8B78_RS10435 (2119762) | 2119762..2120061 | - | 300 | WP_000988336.1 | HNH endonuclease | - |
| K8B78_RS10440 (2120293) | 2120293..2120709 | - | 417 | WP_000590122.1 | hypothetical protein | - |
| K8B78_RS10445 (2120737) | 2120737..2120937 | - | 201 | WP_000265043.1 | DUF1514 family protein | - |
| K8B78_RS10450 (2120937) | 2120937..2121086 | - | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| K8B78_RS10455 (2121083) | 2121083..2121469 | - | 387 | WP_000592207.1 | hypothetical protein | - |
| K8B78_RS10460 (2121466) | 2121466..2121672 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| K8B78_RS10465 (2121709) | 2121709..2122251 | - | 543 | WP_000185659.1 | dUTP pyrophosphatase | - |
| K8B78_RS10470 (2122244) | 2122244..2122426 | - | 183 | WP_000028422.1 | hypothetical protein | Antitoxin |
| K8B78_RS10475 (2122416) | 2122416..2122667 | - | 252 | WP_001065091.1 | DUF1024 family protein | Toxin |
| K8B78_RS10480 (2122660) | 2122660..2122827 | - | 168 | WP_001624242.1 | hypothetical protein | - |
| K8B78_RS10485 (2122839) | 2122839..2123081 | - | 243 | WP_000131366.1 | SAV1978 family virulence-associated passenger protein | - |
| K8B78_RS10490 (2123085) | 2123085..2123453 | - | 369 | WP_000101274.1 | SA1788 family PVL leukocidin-associated protein | - |
| K8B78_RS10495 (2123466) | 2123466..2123775 | - | 310 | Protein_2045 | RusA family crossover junction endodeoxyribonuclease | - |
| K8B78_RS10500 (2123784) | 2123784..2124002 | - | 219 | WP_000338531.1 | hypothetical protein | - |
| K8B78_RS10505 (2124009) | 2124009..2124893 | - | 885 | WP_000148316.1 | DnaD domain protein | - |
| K8B78_RS10510 (2124923) | 2124923..2125393 | - | 471 | WP_000934764.1 | single-stranded DNA-binding protein | - |
| K8B78_RS10515 (2125394) | 2125394..2126011 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
| K8B78_RS10520 (2126092) | 2126092..2127012 | - | 921 | WP_000138472.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / sea / scn / chp / sak / sea / hlb / tsst-1 / groEL | 2068321..2165519 | 97198 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9349.22 Da Isoelectric Point: 3.9473
>T215189 WP_001065091.1 NZ_CP082815:c2122667-2122416 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T215189 NZ_CP110526:c63892-63515 [Klebsiella pneumoniae]
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA
ATGCAAACACAACCTGTTCCTCCGAAACGGGAGGTTTCGCCACGCCCGTCACCCGTGGCGATCTGGCAGCGCCTCCTGAG
TCACCTGCTGGACCGTCACTACGGTCTGACGCTCAACGACACGCCATTTGGCAAAGATGGTGTGATCCAAGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTCATCGTGGAGAAATACGACCTGGTACGCACTGATCGTCGCGGTTTT
AACGCGGAAACTCAGTCGCCGCTTCTCACCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGGCTGATGACCCGTCA
TAGCTACAGGGCCGTTACCGACATCACCACCGGCAAATACCGTGAGGTGCAACCATGA
Antitoxin
Download Length: 61 a.a. Molecular weight: 6741.63 Da Isoelectric Point: 4.2658
>AT215189 WP_000028422.1 NZ_CP082815:c2122426-2122244 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
Download Length: 183 bp
>AT215189 NZ_CP110526:c64301-63942 [Klebsiella pneumoniae]
TTGTCGAATACAATACCGCCTGTAAACCACGATATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTT
TGGCGCACGTCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACG
CGGATTTACGCCATCTCGACCAGGCATTCCCGCTACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGT
CTATCTCGCAATTTACCCGACACCTGCAACAACAGAATAA
TTGTCGAATACAATACCGCCTGTAAACCACGATATCGCCGCCCCTTGGTGGGGGCTTAAACGCGATATCACCCCCTGTTT
TGGCGCACGTCTGGTGCAGGAGGGCAACCGGCTGCATTACCTGAACGACCGCGCCAGCATCACCGGCACCTTCAGCGACG
CGGATTTACGCCATCTCGACCAGGCATTCCCGCTACTGCTGAAGCAACTGGAGCTGATGCTGCTTTCCGGTGAGCTGAAT
CCCCGTCATCAGCACTGCGTCACGCTGTATGCAAAAGGGCTGATATGCGAGGCCGACAGCCTCGGCTCGCACGGGTACGT
CTATCTCGCAATTTACCCGACACCTGCAACAACAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5S9I4Y6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VQM8 |