Detailed information of TA system TA215187

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF2/-
• Location: 2098933..2099232
• Replicon: chromosome
• Accession: NZ_CP082815
• Organism: Staphylococcus aureus strain SCAID WND1-2021 (598)

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K8B78_RS10325
• Protein ID: WP_011447039.1
• Coordinates: 2099056..2099232 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2098933..2098988 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B78_RS10285	2094263..2094523	+	261	WP_001791826.1	hypothetical protein	-
K8B78_RS10290	2094576..2094926	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K8B78_RS10295	2095612..2096061	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K8B78_RS10300	2096156..2096491	-	336	Protein_2006	SH3 domain-containing protein	-
K8B78_RS10305	2097141..2097632	-	492	WP_000919350.1	staphylokinase	-
K8B78_RS10310	2097823..2098578	-	756	WP_000861038.1	CHAP domain-containing protein	-
K8B78_RS10315	2098590..2098844	-	255	WP_000611512.1	phage holin	-
K8B78_RS10320	2098896..2099003	+	108	WP_001791821.1	hypothetical protein	-
-	2098925..2099064	+	140	NuclAT_1	-	-
-	2098925..2099064	+	140	NuclAT_1	-	-
-	2098925..2099064	+	140	NuclAT_1	-	-
-	2098925..2099064	+	140	NuclAT_1	-	-
-	2098933..2098988	+	56	-	-	Antitoxin
K8B78_RS10325	2099056..2099232	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K8B78_RS10330	2099341..2100114	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
K8B78_RS10335	2100535..2100909	-	375	WP_000340977.1	hypothetical protein	-
K8B78_RS10340	2100965..2101252	-	288	WP_001040259.1	hypothetical protein	-
K8B78_RS10345	2101299..2101451	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / scn / chp / sak / sea / hlb / tsst-1 / groEL	2068321..2165519	97198

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T215187 WP_011447039.1 NZ_CP082815:c2099232-2099056 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T215187 NZ_CP110525:91117-92442 [Klebsiella pneumoniae]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Nucleotide

• Length: 56 bp

>AT215187 NZ_CP082815:2098933-2098988 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin