Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF1/- |
| Location | 2098925..2099232 | Replicon | chromosome |
| Accession | NZ_CP082815 | ||
| Organism | Staphylococcus aureus strain SCAID WND1-2021 (598) | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | K8B78_RS10325 | Protein ID | WP_011447039.1 |
| Coordinates | 2099056..2099232 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF1 | ||
| Locus tag | - | ||
| Coordinates | 2098925..2099064 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B78_RS10285 (2094263) | 2094263..2094523 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| K8B78_RS10290 (2094576) | 2094576..2094926 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| K8B78_RS10295 (2095612) | 2095612..2096061 | + | 450 | WP_000727649.1 | chemotaxis-inhibiting protein CHIPS | - |
| K8B78_RS10300 (2096156) | 2096156..2096491 | - | 336 | Protein_2006 | SH3 domain-containing protein | - |
| K8B78_RS10305 (2097141) | 2097141..2097632 | - | 492 | WP_000919350.1 | staphylokinase | - |
| K8B78_RS10310 (2097823) | 2097823..2098578 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| K8B78_RS10315 (2098590) | 2098590..2098844 | - | 255 | WP_000611512.1 | phage holin | - |
| K8B78_RS10320 (2098896) | 2098896..2099003 | + | 108 | WP_001791821.1 | hypothetical protein | - |
| - (2098925) | 2098925..2099064 | + | 140 | NuclAT_1 | - | Antitoxin |
| - (2098925) | 2098925..2099064 | + | 140 | NuclAT_1 | - | Antitoxin |
| - (2098925) | 2098925..2099064 | + | 140 | NuclAT_1 | - | Antitoxin |
| - (2098925) | 2098925..2099064 | + | 140 | NuclAT_1 | - | Antitoxin |
| K8B78_RS10325 (2099056) | 2099056..2099232 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| K8B78_RS10330 (2099341) | 2099341..2100114 | - | 774 | WP_000750406.1 | staphylococcal enterotoxin type A | - |
| K8B78_RS10335 (2100535) | 2100535..2100909 | - | 375 | WP_000340977.1 | hypothetical protein | - |
| K8B78_RS10340 (2100965) | 2100965..2101252 | - | 288 | WP_001040259.1 | hypothetical protein | - |
| K8B78_RS10345 (2101299) | 2101299..2101451 | - | 153 | WP_001153681.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / sea / scn / chp / sak / sea / hlb / tsst-1 / groEL | 2068321..2165519 | 97198 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T215186 WP_011447039.1 NZ_CP082815:c2099232-2099056 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T215186 NZ_CP110524:234977-235261 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA
Antitoxin
Download Length: 140 bp
>AT215186 NZ_CP082815:2098925-2099064 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
