Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | txpA-SprF3/- |
| Location | 2072678..2072977 | Replicon | chromosome |
| Accession | NZ_CP082815 | ||
| Organism | Staphylococcus aureus strain SCAID WND1-2021 (598) | ||
Toxin (Protein)
| Gene name | txpA | Uniprot ID | Q2FWU9 |
| Locus tag | K8B78_RS10135 | Protein ID | WP_011447039.1 |
| Coordinates | 2072801..2072977 (-) | Length | 59 a.a. |
Antitoxin (RNA)
| Gene name | SprF3 | ||
| Locus tag | - | ||
| Coordinates | 2072678..2072733 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K8B78_RS10095 | 2068008..2068268 | + | 261 | WP_001791826.1 | hypothetical protein | - |
| K8B78_RS10100 | 2068321..2068671 | - | 351 | WP_000702263.1 | complement inhibitor SCIN-A | - |
| K8B78_RS10105 | 2069357..2069806 | + | 450 | WP_000727649.1 | chemotaxis-inhibiting protein CHIPS | - |
| K8B78_RS10110 | 2069901..2070236 | - | 336 | Protein_1968 | SH3 domain-containing protein | - |
| K8B78_RS10115 | 2070886..2071377 | - | 492 | WP_000919350.1 | staphylokinase | - |
| K8B78_RS10120 | 2071568..2072323 | - | 756 | WP_000861038.1 | CHAP domain-containing protein | - |
| K8B78_RS10125 | 2072335..2072589 | - | 255 | WP_000611512.1 | phage holin | - |
| K8B78_RS10130 | 2072641..2072748 | + | 108 | WP_001791821.1 | hypothetical protein | - |
| - | 2072670..2072809 | + | 140 | NuclAT_0 | - | - |
| - | 2072670..2072809 | + | 140 | NuclAT_0 | - | - |
| - | 2072670..2072809 | + | 140 | NuclAT_0 | - | - |
| - | 2072670..2072809 | + | 140 | NuclAT_0 | - | - |
| - | 2072678..2072733 | + | 56 | - | - | Antitoxin |
| K8B78_RS10135 | 2072801..2072977 | - | 177 | WP_011447039.1 | type I toxin-antitoxin system toxin PepG1 | Toxin |
| K8B78_RS10140 | 2073086..2073859 | - | 774 | WP_000750406.1 | staphylococcal enterotoxin type A | - |
| K8B78_RS10145 | 2074280..2074654 | - | 375 | WP_000340977.1 | hypothetical protein | - |
| K8B78_RS10150 | 2074710..2074997 | - | 288 | WP_001040259.1 | hypothetical protein | - |
| K8B78_RS10155 | 2075044..2075196 | - | 153 | WP_001153681.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / sea / scn / chp / sak / sea / hlb / tsst-1 / groEL | 2068321..2165519 | 97198 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6849.45 Da Isoelectric Point: 10.6777
>T215184 WP_011447039.1 NZ_CP082815:c2072977-2072801 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK
Download Length: 177 bp
>T215184 NZ_CP110524:190047-190331 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA
ATGACCTATAAGCTGGCTTTCAACGAATCCGCTCTGAAAGAATGGAAGAAGCTGGGTCATACACTACAGGTACAGTTCAA
AAAGAAACTCAAAGAGCGCCTGGAGAACCCCAGAGTTCCGGCATCACAGCTACATGGACGTAAGGACCAGTATAAAATTA
AGCTACGTGGTGCCGGATATCGCCTTGTCTATCGTGTAGAGGACGACATTGTCACAGTCACTGTTATCGGCGTAGGCAAA
CGCGAAAACGACGACATTTATAATGCAACCCTTAATCGCAATTGA
Antitoxin
Download Length: 56 bp
>AT215184 NZ_CP082815:2072678-2072733 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
