Detailed information of TA system TA215183

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2072670..2072977
• Replicon: chromosome
• Accession: NZ_CP082815
• Organism: Staphylococcus aureus strain SCAID WND1-2021 (598)

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K8B78_RS10135
• Protein ID: WP_011447039.1
• Coordinates: 2072801..2072977 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2072670..2072809 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B78_RS10095 (2068008)	2068008..2068268	+	261	WP_001791826.1	hypothetical protein	-
K8B78_RS10100 (2068321)	2068321..2068671	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K8B78_RS10105 (2069357)	2069357..2069806	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K8B78_RS10110 (2069901)	2069901..2070236	-	336	Protein_1968	SH3 domain-containing protein	-
K8B78_RS10115 (2070886)	2070886..2071377	-	492	WP_000919350.1	staphylokinase	-
K8B78_RS10120 (2071568)	2071568..2072323	-	756	WP_000861038.1	CHAP domain-containing protein	-
K8B78_RS10125 (2072335)	2072335..2072589	-	255	WP_000611512.1	phage holin	-
K8B78_RS10130 (2072641)	2072641..2072748	+	108	WP_001791821.1	hypothetical protein	-
- (2072670)	2072670..2072809	+	140	NuclAT_0	-	Antitoxin
- (2072670)	2072670..2072809	+	140	NuclAT_0	-	Antitoxin
- (2072670)	2072670..2072809	+	140	NuclAT_0	-	Antitoxin
- (2072670)	2072670..2072809	+	140	NuclAT_0	-	Antitoxin
K8B78_RS10135 (2072801)	2072801..2072977	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K8B78_RS10140 (2073086)	2073086..2073859	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
K8B78_RS10145 (2074280)	2074280..2074654	-	375	WP_000340977.1	hypothetical protein	-
K8B78_RS10150 (2074710)	2074710..2074997	-	288	WP_001040259.1	hypothetical protein	-
K8B78_RS10155 (2075044)	2075044..2075196	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / scn / chp / sak / sea / hlb / tsst-1 / groEL	2068321..2165519	97198

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T215183 WP_011447039.1 NZ_CP082815:c2072977-2072801 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T215183 NZ_CP110524:c159812-159342 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTATCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGAATCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT215183 NZ_CP082815:2072670-2072809 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin