Detailed information of TA system TA215171

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1986690..1986997
• Replicon: chromosome
• Accession: NZ_CP082813
• Organism: Staphylococcus aureus strain SCAID OTT1-2021 (597/2)

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K8B68_RS09740
• Protein ID: WP_011447039.1
• Coordinates: 1986821..1986997 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1986690..1986829 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B68_RS09700 (1982033)	1982033..1982293	+	261	WP_001791826.1	hypothetical protein	-
K8B68_RS09705 (1982346)	1982346..1982696	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K8B68_RS09710 (1983381)	1983381..1983830	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K8B68_RS09715 (1983925)	1983925..1984259	-	335	Protein_1884	SH3 domain-containing protein	-
K8B68_RS09720 (1984906)	1984906..1985397	-	492	WP_031865878.1	staphylokinase	-
K8B68_RS09725 (1985588)	1985588..1986343	-	756	WP_000861038.1	CHAP domain-containing protein	-
K8B68_RS09730 (1986355)	1986355..1986609	-	255	WP_174841057.1	phage holin	-
K8B68_RS09735 (1986661)	1986661..1986768	+	108	WP_031762631.1	hypothetical protein	-
- (1986690)	1986690..1986829	+	140	NuclAT_0	-	Antitoxin
- (1986690)	1986690..1986829	+	140	NuclAT_0	-	Antitoxin
- (1986690)	1986690..1986829	+	140	NuclAT_0	-	Antitoxin
- (1986690)	1986690..1986829	+	140	NuclAT_0	-	Antitoxin
K8B68_RS09740 (1986821)	1986821..1986997	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K8B68_RS09745 (1987200)	1987200..1987955	-	756	WP_029729062.1	staphylococcal enterotoxin type P	-
K8B68_RS09750 (1988393)	1988393..1988767	-	375	WP_000340977.1	hypothetical protein	-
K8B68_RS09755 (1988823)	1988823..1989110	-	288	WP_001262621.1	hypothetical protein	-
K8B68_RS09760 (1989156)	1989156..1989308	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / see / scn / chp / sak / hlb / groEL	1982346..2015731	33385

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T215171 WP_011447039.1 NZ_CP082813:c1986997-1986821 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T215171 NZ_CP110523:817942-818352 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT215171 NZ_CP082813:1986690-1986829 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin