Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1489231..1489931 Replicon chromosome
Accession NZ_CP082808
Organism Burkholderia contaminans strain SCAID TST1-2021 (11/270)

Toxin (Protein)


Gene name mqsR Uniprot ID A0A1E3FT75
Locus tag K8B66_RS24080 Protein ID WP_039357707.1
Coordinates 1489231..1489527 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A4R4BTY4
Locus tag K8B66_RS24085 Protein ID WP_039357704.1
Coordinates 1489530..1489931 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B66_RS24065 (K8B66_24065) 1485756..1487306 + 1551 WP_039357717.1 sensor domain-containing diguanylate cyclase -
K8B66_RS24070 (K8B66_24070) 1487548..1487832 + 285 WP_039357714.1 hypothetical protein -
K8B66_RS24075 (K8B66_24075) 1488084..1489127 + 1044 WP_039357711.1 succinylglutamate desuccinylase/aspartoacylase family protein -
K8B66_RS24080 (K8B66_24080) 1489231..1489527 + 297 WP_039357707.1 type II toxin-antitoxin system MqsR family toxin Toxin
K8B66_RS24085 (K8B66_24085) 1489530..1489931 + 402 WP_039357704.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
K8B66_RS24090 (K8B66_24090) 1490250..1490810 + 561 WP_039357701.1 GNAT family N-acetyltransferase -
K8B66_RS24095 (K8B66_24095) 1490867..1491814 + 948 WP_039357698.1 ABC transporter substrate-binding protein -
K8B66_RS24100 (K8B66_24100) 1491867..1492916 + 1050 WP_039357696.1 LLM class flavin-dependent oxidoreductase -
K8B66_RS24105 (K8B66_24105) 1492924..1494276 + 1353 WP_223075893.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(72-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11206.04 Da        Isoelectric Point: 8.0535

>T215164 WP_039357707.1 NZ_CP082808:1489231-1489527 [Burkholderia contaminans]
MEKRTPHCKLPRVKALVETGQVRLTASAVLGARLLGFTEREALDVVLSLTDLDFHKSMTTYADHTIWQDVYRPFTVRGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T215164 NZ_CP110517:20216-20632 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14649.94 Da        Isoelectric Point: 8.8304

>AT215164 WP_039357704.1 NZ_CP082808:1489530-1489931 [Burkholderia contaminans]
MKCPACGAARLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGEAITEFNKQVNATIVDPKYIAKVRKK
LKLDQREAAELFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLAEVRAA

Download         Length: 402 bp

>AT215164 NZ_CP110517:19989-20219 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FT75

Antitoxin

Source ID Structure
AlphaFold DB A0A4R4BTY4

References