Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3905464..3906061 Replicon chromosome
Accession NZ_CP082796
Organism Klebsiella pneumoniae strain SCAID PHRX2-2021 (20/245)

Toxin (Protein)


Gene name higB Uniprot ID R4YIC5
Locus tag K8B77_RS18750 Protein ID WP_004142563.1
Coordinates 3905744..3906061 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag K8B77_RS18745 Protein ID WP_004142561.1
Coordinates 3905464..3905751 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B77_RS18715 (3901544) 3901544..3901792 + 249 WP_032445695.1 DUF1158 domain-containing protein -
K8B77_RS18720 (3901810) 3901810..3902151 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
K8B77_RS18725 (3902182) 3902182..3903297 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
K8B77_RS18730 (3903477) 3903477..3904058 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
K8B77_RS18735 (3904058) 3904058..3904426 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
K8B77_RS18740 (3904546) 3904546..3905199 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
K8B77_RS18745 (3905464) 3905464..3905751 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
K8B77_RS18750 (3905744) 3905744..3906061 - 318 WP_004142563.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8B77_RS18755 (3906246) 3906246..3907289 - 1044 WP_016946853.1 DUF2157 domain-containing protein -
K8B77_RS18760 (3907955) 3907955..3908821 - 867 WP_004191455.1 helix-turn-helix transcriptional regulator -
K8B77_RS18765 (3908930) 3908930..3910357 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12110.39 Da        Isoelectric Point: 11.2767

>T215110 WP_004142563.1 NZ_CP082796:c3906061-3905744 [Klebsiella pneumoniae]
MFRLVVHVDVKKELQALPPIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

>T215110 NZ_CP110467:c25632-25273 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAGAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT215110 WP_004142561.1 NZ_CP082796:c3905751-3905464 [Klebsiella pneumoniae]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp

>AT215110 NZ_CP110467:c25273-24974 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M5MXH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References