Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2545856..2546373 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag K3B00_RS12880 Protein ID WP_000113262.1
Coordinates 2545856..2546122 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag K3B00_RS12885 Protein ID WP_000584499.1
Coordinates 2546122..2546373 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3B00_RS12855 (2541279) 2541279..2541815 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
K3B00_RS12860 (2542049) 2542049..2542873 - 825 WP_000572040.1 formate/nitrite transporter family protein -
K3B00_RS12865 (2543090) 2543090..2543272 - 183 WP_000079142.1 hypothetical protein -
K3B00_RS12870 (2543359) 2543359..2543826 - 468 WP_000153344.1 SRPBCC domain-containing protein -
K3B00_RS12875 (2544012) 2544012..2545562 - 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
K3B00_RS14850 (2545750) 2545750..2545821 - 72 WP_223200558.1 hypothetical protein -
K3B00_RS12880 (2545856) 2545856..2546122 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
K3B00_RS12885 (2546122) 2546122..2546373 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K3B00_RS12890 (2546538) 2546538..2546618 - 81 WP_223197974.1 hypothetical protein -
K3B00_RS12895 (2546646) 2546646..2547245 - 600 WP_000162803.1 DsbA family protein -
K3B00_RS12900 (2547264) 2547264..2547626 - 363 WP_000819843.1 DUF4467 domain-containing protein -
K3B00_RS12905 (2547881) 2547881..2549131 + 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
K3B00_RS12910 (2549228) 2549228..2549959 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
K3B00_RS12915 (2549956) 2549956..2550675 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T215071 WP_000113262.1 NZ_CP082789:c2546122-2545856 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T215071 NZ_CP110396:1751143-1752138 [Paraburkholderia sp. D15]
ATGTCCGCAGTTCCGGCCGTTACCGCCGATCCACATGCCGAGCAGGGCACGCAAGCCGGGCTCGAAGCGCGCGTCGCGCG
CTTTCCCGCGCGGCAGGTCCAGCTCGCGTCGCAACGCGTGGTGAGCTATCGCGAAGCGGACGGCGGCAGCCACGGCGATG
CGTTGCCGCTGGTGCTGCTGCACGGTATCGGTTCGGGCGCGGCTTCGTGGGTGCAGCAGTTCGAAGCGCTCGGCGCGACG
CGCCGGGTGCTGGCGTGGGACGCGCCGGGTTATGGCGCATCCACGCCGGTCGAGGCGGCCTCGCCGTGCGCCGGCGATTA
CGCTGCCGTGCTGCGCGAATGGCTCGACGCGTTGGGTATCGAGCGCTGCGTGTTGCTGGGGCATTCGCTCGGCGCGATTG
TGGCGGGTGCGTTTTGCGCTTCGTCGGGTAGCTCAGGGAGCGCCGGTCTCGCCGTCGCCCAGCTGGAACGCGTGGCCGGT
TTGCTGTTGCTGTCGCCGGCCGGCGGTTACGGCGCGGCCCCCGCCGAATTGCGCGACGCGAAGCGCGACCAACGCCTCGC
CATGCTGCGCGATCTCGGCCCGCAGGGTCTCGCCGGGCAACGCAGCGGCAATATGGTGTCCGCTCATGCGAGCGACGAAG
CTCGCGCGTGGGTGCGCTGGAACATGTCGCGCGTGATTCCGCAGGGCTATGAACAGGCGACGCATCTGCTCGCCAATGCC
GACCTCGCCGCCGACCTCGCTCGCTATCGAGCTGGTTTTCAAGCGCGAGTTCAAGCGCAACTGCAAGCGCGGAATGCAGC
GCCCATCGCCATCGCCGTCGGCGCAGAAGACACCATCACGCCCCCTGCCGCCTGCGAGCACCTCGCCCAGGCCGCGGGCG
TGCCGCTTCAGATCGTGCCGCGAGCCGGACACGCCGGCTATATCGAAGCACCCGCCGCTTACACCGCGATCATCGACACA
TTCTGCCGCGCCAGCGACGAACACCGGAGCCAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT215071 WP_000584499.1 NZ_CP082789:c2546373-2546122 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT215071 NZ_CP110396:1752139-1753035 [Paraburkholderia sp. D15]
ATGACGCCCGACCTCACTAACGCCGAACGCGACGCGGACGAAGACCGCAGCGAAACGGGCAACGACGCCGGCAGCGAAAC
CGGCTACCGCGTGCCGGGCCTCGAACGCGGTCTGCGCATCCTCACGGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCAC
CGGAACTGTCCCGCCGCCTGAAGATTCCACGCACGACGGTATTCCGTCTGCTGCAAACGCTCGAATCGCTCGGCTTTCTC
GAACGCGCCGACAAGGACCGCAACTATCGCCTCGGCGTCGCGGTGCTGCGGCTCGGTTTCGAATACCTCAGCTCGCTCGA
ACTGACCGACCTCGGCTTGCCGGTCATCGAAGCGCTGCGCGACGACACCGGCCTCACGACGCACATCGTGATCCGCGACG
GACGCGACGTGGTGTTCGTCGCCAAGGCGCAAAGCCACGCACCGATTTTCAGTTCGGTGAAGGTCAACGTCGGCACGCGT
CTGCCCGCTCATGCGACGACCCACGGCCAGGTGCTGATGGGCGACATGACCATCGACGAACTGAGAAAGCTCTATCCCGA
ACCCGAACTCGAACGCTTCACGAAGCAAACGCCAGTCACGCTCGACGATCTGTACGAACGGATTCGCGACGACGCGCGGC
GCGGTTTCGCGATCAGCGAATCGTCGTTCGAACGCGGCATTTCGGTGGTCAGCGCGCCAGTGCGCAACGACACGGGCCGC
ATCGTCGCGGTGATCACGACGACGATTCCGCGCCACGAGATCGACGCTTCGCTGCTCGACAGCGGCCTGATCGACAAGGT
GCGCCGCGCCGCCGACGAACTCTCGCAACGCCTGAACTACCGGCCGAAGTCGGGTCCGAAGGCGGGCAGCCAATACATGA
AAGCACTGGGGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References